移植免疫中T细胞疫苗作用机制的初步分析  

Preliminary Study on the Mechanism of Immunosuppression in Allograft by T cell vaccination

作　　者：陈永良[1] 何球藻[1] 

机构地区：[1]上海医科大学基础医学院免疫学教研室

出　　处：《上海免疫学杂志》1996年第3期138-141,共4页Shanghai Journal of Immunology

摘　　要：为分析Ｔ细胞疫苗同种兔疫抑制作用的机制，在体外观察了Ｔ细胞疫苗免疫小鼠细胞免疫应答能力的改变，分别在ＭＩＣ实验中，观察了免疫小鼠血清和免疫小鼠脾细胞对同种应答细胞反应能力的影响。结果表明：免疫小鼠淋巴细胞ＣｏｎＡ转化反应能力及同种抗原反应能力均显著降低，免疫小鼠血清及其脾细胞不同程度地抑制了同种应答细胞的反应能力，但以上作用并未表现出抗原特异性。An attempt was made in this paper to analyse preliminarily the immunosuppressive effect of vaccination with T cells that could prolong the cardiac allograft survival. It was found that the proliferation responses to ConA or to alloantigen of the splenocytes from TCV immunized mice was lower than those from normal mice. The sera and splenocytes from TCV immunized mice had the obvious inhibitory effect on the lymphocyte proliferation response to ConA or to the alloantigen in MLR. The possibilities of the inhibitory effect by immunization with T cell vaccination have been discussed.

关 键 词：移植免疫 T细胞疫苗 T抑制细胞 

分 类 号：R392.4[医药卫生—免疫学]