1，6二磷酸果糖对胃肠灌注与全身炎性反应关系的探讨  

Relationship between fructose-1,6-diphosphate and gastrointestinal reperfusion and systemic inflammatory response

作　　者：邹捍东[1] 程帮昌[1] 周敏[2] 周晨亮[1] 侯伟[3] 

机构地区：[1]武汉大学人民医院麻醉科,湖北武汉430060 [2]湖北省咸丰县人民医院 [3]武汉大学病毒研究所

出　　处：《中国医师杂志》2007年第2期154-156,共3页Journal of Chinese Physician

摘　　要：目的探讨1，6-二磷酸果糖（FDP）对小儿心脏手术体外循环（CPB）期间胃肠灌注与全身炎性反应的关系。方法择期心内直视手术1～12岁患儿30例，随机分为对照组（T组）和治疗组（F组），F组静注FDP，对照组静注等容量生理盐水。于切皮前（T0）、主动脉开放1h（R1）、2h（R2）检测胃黏膜pH（pHi）、血浆二胺氧化酶（DAO）、血浆内毒素（LPS）、血清IL-6水平。结果T0时2组胃pHi、血DAO、LPS、IL-6差异无统计学意义（P〉0．05）；2组R1、R2时胃pHi值低于T0值（P〈0．05），血DAO、LPS及IL-6高于T0值（P〈0．05）；F组R1、R2时胃pHi值高于T组（P〈0．05），血DAO、LPS及IL-6低于T组（P〈0．05）。结论FDP对小儿心脏手术CPB期间胃肠道具有保护作用，并可抑制全身炎性反应。Objective To explore the relationship between gastrointestinal reperfusion and systemic inflammatory response and fructose-1,6-diphosphate（FDP） injection in pediatric patients undergoing heart surgery during cardio-pulmonary bypass. Methods 30 pediatric patients undergoing elective heart surgery were divided into control group and FDP group randomly. FDP was injected in FDP group, and patients in control group were injected with normal saline in shell volume. Gastric intramucosal pH value （pHi）,blood diamine oxidase （DAO）, blood lipopoly-saccharide（ LPS）, and blood IL-6 were measured before CPB（ T0 ）, 1 h after artery opening （ R1 ）, 2h after artery opening（R2 ）. Results At R1 and R2, the pHi in control group was significantly lower than that of To （ P 〈 0. 05 ）. Blood DAO, LPS and IL-6 were significantly higher than those of To （ P 〈 0. 05 ）. In FDP group , pHi at R1, R2 was significantly higher than that of control group （ P 〈 0. 05 ）. Blood DAO, LPS and IL-6 were significantly lower than those of control group（ P 〈 0. 05 ）. Conclusions FDP can protect gastro intestine and inhibit systemic inflammatory response in pediatric patients undergoing heart surgery during cardio-pulmonary bypass.

关 键 词：果糖二磷酸盐类/药理学 灌注 局部 插管法 胃肠 脓毒症综合征 

分 类 号：R726[医药卫生—儿科]