狼疮性肾炎患者血浆中P选择素检测的临床意义  

Clinical Significance of Detection of Soluble Adhesion Molecules in Lupus Nephritis

作　　者：周同[1] 李晓[1] 钱萍[1] 付秀兰[1] 陈楠[1] 王鸿利[1] 董德长[1] 

机构地区：[1]上海第二医科大学附属瑞金医院

出　　处：《上海免疫学杂志》1996年第3期173-175,共3页Shanghai Journal of Immunology

基　　金：卫生部科研基金

摘　　要：采用双抗体夹心法ＥＬＩＳＡ检测３５例狼疮性肾炎（ＬＮ）患者血浆可溶性粘附分子Ｐ选择素含量，结果发现ＬＮ＇患者血浆Ｐ选择素水平较正常对照增高，其中ＬＮ肾病综合征型和肾功能不全型的上述水平又显高于无症状型和肾炎型。对部分患者进行动态观察，发现经治疗病情改善者血浆Ｐ选择素水平降低。本文证实ＬＮ患者体内不同程度存在内皮细胞、血小板激活状态。检测血浆Ｐ选择素可能对判断或监测ＬＮ患者血栓形成状态、病情进展及活动转归等具有重要意义。The contents of soluble adhesion molecule p-selectin in plasma of 35 patients with lupus nephritis(LN) were measured by a sandwich ELISA. Experimental result showed that the plasma level of p-selectin was markedly increases in LN when compared to that of healthy control, and the increases were much more significant in patients with nephritic syndrome or renal function deficiency than those with no symptom or nephritis. The plasma p-selectin levels were decreased in patients as their clinical condition improved after treatment. This study indicated that there might be an activation of endothelial cells and platelets in patients with LN. The detection of p-selectin is supposed to be impotant for determining or monitoring the thrombogenesis and progress of disease in LN.

关 键 词：粘附分子 P选择素 狼疮性肾炎 血栓形成 

分 类 号：R593.242[医药卫生—内科学]