被动型Heymann肾炎大鼠外周血淋巴细胞诱生IL－2水平的动态观察  

A Dynamic Observation on the interleukin-2 Levels induced by Peripheral Blood Lymphocytes in Passive Heymann Nephritis of Rats

作　　者：陈书芬[1] 孙君江[1] 阴东平[1] 张建明 

机构地区：[1]南京医科大学附属南京第一医院肾内科,南京铁道医学院附属医院肾科,南京市第一医院中心实验室,南京铁道医学院病理教研室

出　　处：《上海免疫学杂志》1996年第4期221-223,共3页Shanghai Journal of Immunology

摘　　要：为了检测被动型ｎｅｙｍａｎｎｇ肾炎（ＰＨＮ）大鼠细胞免疫状况，我们将抗肾小管刷状缘的抗体腹腔注射大鼠体内而建立了被动Ｈｅｙｍａｎｎ肾炎模型，在ＰＨＮ的最初２８ｄ，用ＭＴＴ比色法检测了７ｄ．１４ｄ、２８ｄ时外周血淋巴细胞诱生ＩＬ－２水平的变化，结果７ｄ时ＩＬ－２水平为２６．５２±１０．７２Ｕ／ｍｌ，与正常对照组３９．８０±９．４０Ｕ／ｍｌ相比显著差异（Ｐ＜０．０１），１４ｄ时ＩＬ－２水平为３０．６８±１１．７９Ｕ／ｍｌ（Ｐ＜Ｏ．０５），２８ｄ时ＩＬ－２水平为３２．７２±８．７２Ｕ／ｍｌ（Ｐ＜０．０５），提示ＰＨＮ大鼠存在免疫功能紊乱。Passive Heymann Nephritis(PHN)of rat model was established by injection antiserum against proximal tubular brush border antigen to rats peritoneally,and the levels of interleukin-2 induced by peripheral blood lymphocytes were measured.Theresults showed that the IL-2 levels in PHN rats were lower than those of normalrats,suggesting that PHN rats might have somewhat dysfunctions in cellular immunity.

关 键 词：肾炎 HEYMANN肾炎 白细胞介素2 淋巴细胞 

分 类 号：R692.390.3[医药卫生—泌尿科学]