分枝杆菌多糖免疫调节作用的临床应用研究  

The immunoregulatory function of mycobacterial polysaccharides in clinical usage

作　　者：赵文明[1] 陈仁[1] 诸小侬[2] 张永珩[2] 鲍云[3] 

机构地区：[1]首都医科大学免疫学研究室,北京100054 [2]北京市同仁医院 [3]北京市佑安医院

出　　处：《中华微生物学和免疫学杂志》1996年第6期438-441,共4页Chinese Journal of Microbiology and Immunology

摘　　要：分枝杆菌多糖（Ｍｙｃｏbａｃｔｅｒｉａｌ ｐｏｌｙｓａｃｃｈａｒｉｄｅｓ，ＭＰＳ） 是由非致病性分枝杆菌中提取的多糖成分制成的一种免疫调节剂。作者报道ＭＰＳ在临床试用中的免疫调节效果。用于８５例术后化疗的肿瘤患者能明显提高白细胞水平和保护细胞免疫功能（Ｐ）＜０．０５～０．０１）；用于６７例乙型肝炎患者及ＨＮＶ携带者，ＨＢｅＡｇ的阴转率为４７．８％；用于３１例反复呼吸道感染易感儿，可明显提高其ＣＤ４细胞数和ＣＤ４／ＣＤ８比值（Ｐ＜０．０１）。上述结果提示，ＭＰＳ可能适用于化疗患者的白细胞回升、慢性乙型肝炎的治疗及提高低下的免疫功能。Mycobacterial polysaccharides ( MPS ) is an immunoregulatory agent extracted from a strain of non-pathogenic mycobacteria. This paper reported the immunoregulatory effect of MPS in clinical usage. After treatment with MPS of 85 cases suffering from malignant neoplasms treated with chemotherapy after operation , the level of leukocytes and the cell mediated immunity were raised obviously (P< 0. 05～ 0. 01 ) . After treatment with MPS of 67 cases of hepatitis B and HBV carriers , 47. 8％ HBeAg positive patients and carriers became negatively converted . MPS was also used to treatment for the repeated respiratory tract in fections in 31 cases of children , the percentage of CD4 cells and the ratio of CD4/CD8 were raised obviously (P<0. 01). All of the results indicate that MPS may be used in patients with decreased WBC count after chemotherapy . immunodysfuction and chronic hepatitis B.

关 键 词：分枝杆菌 多糖 肿瘤 乙型肝炎 增加白细胞 免疫 

分 类 号：R979.5[医药卫生—药品]