重组人粒细胞集落刺激因子对6．5Gy不均匀照射狗造血影响的研究  

Haematological effects of rhG-CSF on dogs exposed to 6.5Gy uneven γ-radiation

作　　者：罗庆良[1] 夏贞彪[1] 董波[1] 从玉文[1] 张浩[1] 白蕴红[1] 王德文[1] 毛秉智[1] 

机构地区：[1]北京放射医学研究所

出　　处：《中华放射医学与防护杂志》1996年第3期170-172,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：观察了重组人粒细胞集落刺激因子（ｒｈＧ－ＣＳＦ）对屏蔽全骨盆后６．５Ｇｙ６０Ｃｏγ射线照射狗的治疗作用。结果表明，ｒｈＧ－ＣＳＦ可使急性放射病狗造血恢复明显提前，恢复速度加快。The stimulative effects of recombinant human granulocyte colony stimulating factor(rhG-CSF)on haematopoietic regeneration were studied in dogs receiving an uneven γ-irradiation with the pelvis shielded at a dose of 6.5Gy.In the treated dogs ,intravenous administration of rhG-CSF at 5 or 10μg/kg per day for 16 to 20 days caused significant increases of peripheral blood leucocytes, neutrophils,reticulocytes,and platelets.The nucleated cell and CFU-GM cornts of bone marrow also showed an obvious rise,while the hemoglobin level did not significantly change during the course of treatment.In the irradiated dogs treated with rhG-CSF,the severity of neutropenia decreased,and its duration shortened.

关 键 词：钴60 急性放射病 6.5Gy 粒细胞 集落刺激因子 

分 类 号：R818.71[医药卫生—放射医学] R818.052[医药卫生—临床医学]