HG颗粒对CCl_4复合因素所致肝纤维化大鼠血清Hyp及TGFβ_1含量的影响  

Effects of HG Keli on Hyb and TGFβ_1 in the Blood of HP Model Rats Induced ByCarbon Tetrar-chloride Compounded other Factors

作　　者：毕红征[1] 赵君玫[2] 黄国钧[3] 

机构地区：[1]郑州大学实验动物中心,河南郑州450052 [2]河南中医学院,河南郑州450008 [3]成都中医药大学药学院,四川成都610075

出　　处：《河南中医学院学报》2007年第2期29-31,共3页Journal of Henan University of Chinese Medicine

摘　　要：目的:研究HG颗粒对肝纤维化(hepatic fibrosis)大鼠血清羟脯氨酸(Hyp)及转化生长因子β1(TGFβ1)含量的影响。方法:大鼠皮下注射CCl4,同时给予高脂饲料和20%乙醇喂养建立肝纤维化大鼠模型,分别予HG颗粒、复方鳖甲软肝片灌胃治疗。对照观察两药物对肝纤维化模型大鼠血清Hyp及TGFβ1含量的影响。结果:肝纤维化模型大鼠血清Hyp及TGFβ1含量均明显增高。HG颗粒治疗后有明显缓解,综合疗效优于阳性药物对照组。结论:HG颗粒对CCl4复合因素所致肝纤维化模型大鼠具有显著的治疗作用。Objective To explore the effects of HG Keli on Hyb and TGFβ1 in the blood of kiP models rats, Methods Established kiP model rats were induced hypodermicly by injected carbon tetrar-chloride, at the same time feed with the high fat feed and 20% ethyl alcohol, Trended the HP rats with HG Keli and FuFangBieJiaRuanGan tablets respectivly through tube feeding. Obseved the contents of of Hyb and TGFβ1 in the blood. Results Contents of Hyb and TGFβ1 in the blood of model rats were significantly higher than the normal group. After the therpy of HG Keli, the Contents of Hyb and TGFβ1 in the blood decreased markedly, the comprehensive action of HG Keli was better than that of modem medicine. Conclusion These results suggested that HG Keli can effectively cure kiP model rats induced by carbon tetrar-chloride compounded other factors.

关 键 词：HG颗粒 羟脯氨酸 转化生长β1 

分 类 号：R285.5[医药卫生—中药学]