壳聚糖-巯基醋酸偶合物的巯基含量与体外黏附性关系研究  

Research on the relation between the content of thiol group and in vitro adhesion of the chitosan-thioglycolic acid conjugates

作　　者：袁干军[1] 苏秋玲 黄红谦[1] 沈行良[1] 刘明生[1] 陈德梅[1] 

机构地区：[1]海南医学院,海南海口571101 [2]海南爱科制药有限公司,海南海口571102

出　　处：《中国海洋药物》2007年第1期20-23,共4页Chinese Journal of Marine Drugs

基　　金：海南省卫生厅项目(琼卫2005-10);海南医学院苗圃基金(200308)

摘　　要：目的考察壳聚糖-巯基醋酸偶合物的巯基含量与体外黏附性的关系。方法制备了不同巯基含量的壳聚糖-巯基醋酸偶合物,分别对其溶胀性和制成测试片与黏膜分离时的瞬间拆分力进行测定,记录最大拆分力,并计算出总黏附功。结果壳聚糖-巯基醋酸偶合物的体外黏附性与巯基含量呈正相关,随着偶合物中巯基含量的增加,偶合物的黏附性呈非线性增加,增加的速度越来越小。结论高巯基含量的壳聚糖-巯基醋酸偶合物黏附性远强于壳聚糖。Objective Research on the relation between the content of thiol group in chitosan-thioglycolic acid conjugates and in vitro adhesion. Methods Prepared chitosan-thioglycolic acid conjugates with different content of thiol group, and determined the swelling behavior, instant detachment force between test disc and mucosa, recorded the maximum detachment force（MDF）, and calculated the total work of adhesion（TWA）of these samples. Results The relation between the content of thiol groups and in vitro adhesion of the chitosan-thioglycolic acid conjugates was positive correlation, the adhesion of the polymer increased along with the content of thiol group, but the rate decreased. Conclusion The adhesion of chitosan-thioglycolic acid conjugates with higher content of thiol gyoup was far more stronger than chitosan.

关 键 词：壳聚糖-巯基醋酸偶合物 巯基 黏附性 

分 类 号：R943.5[医药卫生—药剂学]