手性化合物的非目标对映体转化  

Conversion of unwanted enantiomers of chiral compounds

作　　者：白国义[1] 张晨芳[1] 陈立功[2] 张月成[2] 

机构地区：[1]河北大学化学与环境科学学院,河北保定071002 [2]天津大学化工学院,天津300072

出　　处：《现代化工》2007年第2期66-69,共4页Modern Chemical Industry

基　　金：国家自然科学基金资助项目(20376057);河北省教育厅科研计划项目(2005350)

摘　　要：介绍了通过构型反转和外消旋化反应对手性醇类、氨基醇类和氨基酸类化合物的非目标对映体进行转化的最新研究进展。构型反转能够直接得到所需要的对映体,效率高,但其应用局限性较大;而催化外消旋化反应的应用范围更加广泛,尤其是将金属配合物与酶联用的动态动力学拆分法使消旋率达到了100%,并最终直接得到所需构型的对映体,应是今后研究的重点,同时固定床连续外消旋化的方法也具有良好的应用前景。The latest progress in the conversion of the unwanted enantiomers of chiral alcohols, amino alcohols and amino acids are reviewed in this paper. The two most valuable methods are configuration inversion and racemization. The configuration inversion can offer the desired enantiomer in high efficiency, but with certain limitation in apphcafion. Whereas, the catalytic racemization has broader application,especially for the dynamic kinetic resolution,which can reach a 100% rate of racemization and finally offer the desired enantiomer by the combination of metal complex with enzyme. Both the dynamic kinetic resolution and the continuous fixed-bed racemization are regarded to have wide apphcation prospects after certain improvements.

关 键 词：非目标对映体 构型反转 外消旋化 

分 类 号：TQ032[化学工程]