2型糖尿病患者血清白介素-18肿瘤坏死因子-α与胰岛素抵抗的相关性研究  

Study of Association Between Serum Interleukin-18,TNF-α and Insulin Resistance in type 2 Diabetes Mellitus

作　　者：汪玲[1] 郑绍同[1] 陈敏[1] 

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《黑龙江医学》2006年第10期735-737,共3页Heilongjiang Medical Journal

摘　　要：目的探讨2型糖尿病患者的血清白介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)与胰岛素抵抗(IR)的关系。方法选择62例2型糖尿病患者和40例正常对照组,测定各组空腹血清IL-18、TNF-α水平,同时检测空腹血糖(FPG)、胰岛素(FINS)、血脂,测量身高、体重、腰围、臀围计算体重指数(BMI)、腰臀比(WHR),采用HOMA-IR模型公式计算胰岛素抵抗指数。结果2型糖尿病患者的血清IL-18、TNF-α、FPG、FINS及HOMA-IR水平显著高于对照组(P<0.01),经相关性分析IL-18水平与BMI和WHR呈正相关,血清IL-18、TNF-α均与HOMA-IR呈正相关。结论IL-18、TNF-α是糖尿病患者IR的独立影响因素,2型糖尿病患者血浆IL-18、TNF-α水平升高可间接反映胰岛素抵抗程度。Objective To assess the assouation of serum Interliukin - 18,TNF- a and insulin resistance in type 2 diabetes mellitus.Methods 62 T2DM patients and 40 non- diabetic controls were selected levels of Interliukin- 18,TNF-α meal measured. Fasting blood glucose and fasting insulin, blood lvpid, BMI and WHR were measured. Homa - IR were calculated.Results The levels of serum Interliukin - 18,TNF-α and Homa - IR in T2DM group were significantly higher than those in control group. IL- 18 and TNF -α level of serum was positively corrdated with Homa - IR. IL - 18 level of serum was positively associated with BMI and WHR. Conclusion IL- 18, TNF -α independent risk foctors for IR may be involved in T2DM development, and it could reflect the degree of insuhn resistance indirectly.

关 键 词：IL-18 TNF-Α 2型糖尿病 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]