矽尘、亚硒酸钠对人肺腺癌细胞株生长的影响  

EFFECT OF SILICA DUST AND SODIUM SELENITE ON SPC-A-1 GROWTH

作　　者：巢健茜[1] 高锦伍[1] 赵进顺[1] 田世兰[1] 

机构地区：[1]江苏省职工医科大学卫生管理学教研室,南京铁道医学院劳动卫生学教研室

出　　处：《工业卫生与职业病》1996年第6期334-336,共3页Industrial Health and Occupational Diseases

摘　　要：本文通过细胞培养分析了亚硒酸钠、二氧化硅尘对人肺腺癌细胞株ＳＰＣ－Ａ－１的作用，结果表明：（１）在培养液中加入不同剂量的亚硒酸钠，１μｍｏ１／Ｌ对细胞株生长无影响，５μｍｏｌ／Ｌ、１０μｍｏ１／Ｌ对细胞株的生长有明显抑制作用（Ｐ＜０．０５），４０μｍｏ１／Ｌ有明显毒性，且随着培养时间的延长，其抑制程度增加。（２）随着ＳｉＯ２剂量的增加，二氧化硅尘对人肺腺癌细胞株生长的影响越大。生理盐水对细胞株生长无影响。Relations between silica dust and sodium selenite and SPC-A-1 vitro culture were analyzed.The results showed that the addition of different doses of sodium selenite revealed different effects.1μmol/L had no effect while 5μmol/L and 10μmol/L had distinct inhibitive effect( P< 0.05 ) . 40μmol/L had distinct toxicity. Moreover, the inhibition increased with the length of culturing time. 0.33mmol/L,0.67mmol/L and 1.33 mmol/L had accelerating effects on SPC-A-1 growth,the last two doses showed more obviously, The effects increased with the increase of silica doses,and the saline solution had no accelerating effect on SPC-A-1 growth. The results was somewhat meaningful in the study of induction of cancer by silica dust and the preventive effect of sodium selenite to lung cancer.

关 键 词：矽尘 亚硒酸钠 肺腺肿瘤 细胞 生长 

分 类 号：R135.2[医药卫生—劳动卫生] R734.202[医药卫生—公共卫生与预防医学]