颅脑损伤患者血清可溶性E-选择素变化及其意义  

Changes of serum soluble E-selectin and its significance in the patients with head injury

作　　者：王向东[1] 张建生[1] 丁永忠[1] 袁治[1] 王博[1] 

机构地区：[1]兰州大学第二医院神经外科神经病学研究所,730030

出　　处：《中国急救医学》2007年第2期115-117,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的研究颅脑损伤后E-选择素的变化和意义。方法采用酶联免疫吸附法（ELISA）对30例重型颅脑损伤（GCS3～8分）和25例轻-中型颅脑损伤（GCS9～15分）患者连续测定伤后12、24、48、72、96h血清可溶性E-选择素和预后评分（GOS）。观察可溶性E-选择素与COS之间的关系。结果重型颅脑损伤组在伤后12h可溶性E-选择素水平最高，连续96h高于正常（P〈0.05），升高水平明显高于轻-中型颅脑损伤组。伤后12h可溶性E-选择素〉60μg/L的患者预后明显不良（P〈0.05）。结论可溶性E-选择素水平在颅脑损伤后明显升高，而且与预后相关。Objective To investigate the changes of serum soluble E - selectin （ sES） in the patients following head injury. Methods sES was measured in 30 patients with Glasgow Coma Scale （ GCS） between 3 -8 and 25 patients with GCS between 9 - 15 within 12,24,48,72,96 hours after head injury by enzyme - linked immunosorbent assay （ ELISA ）. The relationship between sES and Glasgow Outcome Scale （ GOS） were studied. Results sES in the patients with GCS between 3 - 8 was the highest within 12 hours after head injury （ P 〈 0.05）, and it was still higher on the 4rd day after head injury （ P 〈 0.05 ）. The outcome of the patients with sES 〉 60 μg/L was poorer than that of the patients with sES 〈 60 μg/L （ P 〈 0.05）. Conclusion Serum level of sE - selectin is elevated in the patients with head injury, which correlated with the outcome of the patients.

关 键 词：颅脑损伤 可溶性E-选择素 预后 

分 类 号：R651.15[医药卫生—外科学]