不同病因致急性肺损伤患儿可溶性细胞间黏附分子-1的变化和临床意义  

Changes of serum soluble intercellular adhesion molecule-1 level between the children with acute lung injury caused by pulmonary disease and extra-pulmonary disease and its clinical significance

作　　者：叶璟[1] 韩国强[1] 南向珍[1] 严纯雪[1] 潘国权[1] 

机构地区：[1]温州医学院附属育英儿童医院ICU,浙江325027

出　　处：《中国急救医学》2007年第2期178-180,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨肺内外原因引起的急性肺损伤(ALI)患儿可溶性细胞间黏附分子-1(sICAM-1)的变化及临床意义。方法肺内源性ALI患儿32例,肺外源性ALI患儿35例,使用ELISA双抗体夹心法动态检测ALI诊断成立后1、24、48、72h血清sICAM-1的表达。结果两组患儿在确诊ALI后sICAM-1均较正常值明显升高(P<0.01),肺外源性ALI患儿在确诊ALI1h时sICAM-1即开始明显升高,24h达高峰,至48h开始逐渐下降,1h和24h的sICAM-1较肺内源性ALI患儿明显升高(P<0.01),而sICAM-1在肺内源性ALI患儿的整个疾病过程中变化不明显(F=1.88,P>0.05)。结论肺内、外源性ALI患儿外周血中sICAM-1浓度的变化有明显差异。Objective To explore the differences of serum soluble intercellular adhesion molecule- 1 （ sICAM -1） level between the children with acute lung injury（ ALI） caused by pulmonary disease and extra - pulmonary disease and its clinical significance. Methods The study included 32 children with pulmonary ALI and 35 children with extra - pulmonary ALI in PICU. The serum sICAM - 1 level was measured by ELISA. The samples were collected at four different times （ 1, 24, 48 and 72h after ALI was diagnosed）. Results The levels of sICAM - 1 in two groups were significantly higher than those in the normal group （ P 〈 0.01 ）. In the children with extra - pulmonary ALI, the serum sICAM - 1 level increased significantly at 1 h, reached peak at 24 h, and decreased gradually at 48h after ALI was diagnosed, but there were no significant changes in sICAM - 1 level of pulmonary ALI group （ F = 1.88, P 〉 0. 05 ）. The serum sICAM - 1 at 1 and 24 h in extra - pulmonary ALI group was significantly higher than that in the pulmonary ALI group（P 〈 0.01）. Conclusion The serum sICAM- 1 level was different between the children with ALI caused by pulmonary disease and extra - pulmonary disease.

关 键 词：肺损伤 可溶性细胞间黏附分子-1 病因 

分 类 号：R725.6[医药卫生—儿科]