被动吸烟对血管内皮舒张功能和血浆CRP的影响  

Effect of vascular endothelial dilatation function in healthy young adults and plasma CRP concertration in passive smokers

作　　者：刘爱玲 马红[2] 王文丽 陈伟 屈娟娟 

机构地区：[1]解放军第一五三中心医院特诊理疗科,河南郑州450042 [2]武警河南总队医院特诊科,河南郑州450052

出　　处：《中国实验诊断学》2007年第3期294-296,共3页Chinese Journal of Laboratory Diagnosis

基　　金：河南省科技攻关计划资助项目(0496410036)

摘　　要：目的探讨被动吸烟对健康青年人血管内皮舒张功能和血浆C反应蛋白(CRP)的影响。方法采用超声肱动脉内径测量法,观察被动吸烟、主动吸烟及正常对照组各30例血流介导的和硝酸甘油介导的肱动脉内径变化;同时测定血浆CRP含量。结果三组肱动脉内径基础值及硝酸甘油介导的肱动脉舒张均无显著差异(P>0.05),而血流介导的血管扩张被动吸烟组与正常对照组间存在显著差异(P<0.01),与吸烟组无显著性差异(P>0.05)。主、被动吸烟组血浆CRP含量均高于正常组(P<0.05),而两组间个指标含量无显著性差异。结论被动吸烟导致健康青年人群血管内皮舒张功能损伤可能与血浆CRP含量增加有关。Objective Effect of vascular endothelial dilatation function in healthy young adults and C-reactive protein（CRP） in passive smokers. Methods Brachial artery, internal diameters were measured by ultrasonic. Observe changes of brachial artery internal diameters by flow-mediated and Nitroglycerin-induced in passive smoker group, active smoker group, and control group （each 30 cases）. And measure CRP of each groups. Results Brachial artery basic internal diameters and brachial artery dilatation by Nitroglycerin-indueed are no significant difference among three groups（ P 〉 0.05）. Changes of brachial artery internal diameters by flow-mediated are significant difference between passive smoker group and control group（ P 〈 0.01 ）, while no significant difference between passive smoker group and active smoker group（ P 〉 0.05）. CRP increased in passive smoker group and active smoker group, and no significant difference between two groups. Conclusion Passive smoking induces healthy young-adult to damage vascular endothelial dilatation function. Probably it relates to plasma CRP concentration increase.

关 键 词：高频超声 被动吸烟 吸烟 血管内皮舒张功能 C-反应蛋白 

分 类 号：R543[医药卫生—心血管疾病]