新型鹅去氧胆酸分子裂缝的设计合成  

Design and synthesis of novel molecular clefts based on chenodeoxycholic acid

作　　者：刘兴利[1] 赵志刚[1] 陈淑华[2] 

机构地区：[1]西南民族大学化学与环境保护工程学院,四川成都610041 [2]四川大学化学学院,四川成都610064

出　　处：《化学研究与应用》2007年第3期330-333,共4页Chemical Research and Application

基　　金：国家自然科学基金(20272038)资助项目

摘　　要：A novel type of chiral molecular clefts was designed and synthesized by using chenodeoxycholic acid as spacer and aromatic compounds as arm.Their structures were confirmed by 1H NMR,IR,MS spectra and elemental analysis.Enantioselective recognition properties of these molecular clefts for amino acid methyl esters were investigated by UV-vis spectra titration. The results indicated that these molecular clefts not only recognize all amino acid methyl esters examined but also possess higher selectivity for L-amino acid methyl esters than for D-amino acid methyl esters.A novel type of ehiral molecular clefts was designed and synthesized by using ehenodeoxyeholic acid as spacer and aromarie compounds as arm. Their structures were confirmed by ^1H NMR, IR, MS spectra and elemental analysis. Enanrioseleetive recognition properties of these molecular clefts for amino acid methyl esters were investigated by UV-vis spectra titration. The resuits indicated that these molecular clefts not only recognize all amino acid methyl esters examined but also possess higher selectivity for L-amino acid methyl esters than for D-amino acid methyl esters.

关 键 词：鹅去氧胆酸 分子裂缝 合成 分子识别 

分 类 号：O641.3[理学—物理化学]