缬沙坦对大鼠心肌梗死后心室重构的影响  

Effect of valsartan on ventricular remodeling in rats after myocardial infarction

作　　者：张利群[1] 贾志梅[1] 王洪涛[1] 汪薇[2] 

机构地区：[1]中国医科大学附属第一医院心脏内科,辽宁沈阳110001 [2]中国医科大学实验技术中心

出　　处：《中国医科大学学报》2007年第1期57-58,61,共3页Journal of China Medical University

摘　　要：目的:探讨缬沙坦对大鼠心肌梗死(MI)后心室重构和左室非梗死区(LVNIZ)心肌血管紧张素Ⅱ(AngⅡ)及醛固酮(Ald)的影响。方法:选取雌性Wistar大鼠结扎左冠状动脉,建立MI模型。术后将存活大鼠随机分为缬沙坦组给予缬沙坦15mg·kg-·1d-1直接灌胃给药,另设MI组、假手术组分别灌等量自来水,连续4周。心脏标本病理分析,测定左室截面直径(LVTD),VG染色测定LVNIZ的胶原容积分数(CVF),放免法测定LVNIZ的AngⅡ、Ald含量。结果:与假手术组比较,MI组LVTD(P<0.01)、CVF(P<0.01)、AngⅡ(P<0.05)及Ald(P<0.01)含量均显著增加;缬沙坦使增加的LVTD(P<0.05)、CVF(P<0.05)、AngⅡ(P<0.05)、Ald(P<0.01)显著降低。结论:缬沙坦可能通过抑制心肌局部AngⅡ及Ald的过表达而逆转心室重构。Objective：To investigate the effect of valsartan on ventricular remodeling and angiotensin Ⅱ and aldostemne in non-infarcted myocardium of left ventricle after myocardial infarction （MI）. Methods：The rat model of MI was established by ligating the left coronary artery in female Wistar rots. Three hours after the ligation,21 survived rots were randomly divided to MI group,valsartan group,and sham operation group. The rots were lavaged with 15 mg·kg^-1·d^-1 valsartan in valsartan group and tap water in MI and sham operation groups for 4 weeks. The left ventricular transverse diameter （LVTD）, which indicates the changes of left ventricular structure, was detected. The collagen volume fraction （CVF） in non-infarcted myocardium was detected after HE staining,and the contents of angiotensin Ⅱ and aldosterone in non-infarcted myocardium were determined with mdioimmunoassay. Results： Compmed with sham operation group, LVTD, CVF,and the con tents of angiotensin Ⅱ and aldostemne were all significantly increased in MI group. LVTD, CVF, and the contents of angiotensin Ⅱ and aldostemne in valsartan group were all significantly lower than those in MI group. Conclusion： Valsartan may improve the ventricular remodeling after MI by inhibiting the overexpression of angiotensin Ⅱ and aldostemne.

关 键 词：缬沙坦 心肌梗死 心室重构 

分 类 号：R542.2[医药卫生—心血管疾病]