小剂量激素替代治疗对绝经早期妇女生理、心理健康的影响  

Effect of low-dose hormone replacement therapy on physiological and psychological health in women at early stage of menopause

作　　者：赵岩[1] 吴颖[1] 李秀芹[1] 张淑兰[1] 徐荣春[2] 刘津[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]大庆油田总医院妇产科

出　　处：《中国医科大学学报》2007年第1期76-77,共2页Journal of China Medical University

基　　金：辽宁省教育厅青年基金资助项目(05L549)

摘　　要：目的:探讨小剂量激素替代(HRT)治疗对绝经早期妇女生理、心理健康的影响。方法:选择绝经早期有明显症状和不同程度心理症状的病人40例。每天口服倍美力0.3mg及安宫黄体酮片2mg,同时口服钙剂6个月,于治疗前后分别填写临床症状调查表和心理症状自评量表(SCL-90),比较用药前后临床症状和SCL-90各项指标的变化,做相关性分析;通过B超监测其安全性。结果:小剂量HRT治疗前后比较临床症状和SCL-90各项指标均有显著差异(P<0.05,P<0.01)。临床症状与心理症状存在相关性(P<0.01)。在治疗过程中子宫内膜未见增生。结论:小剂量HRT能安全、有效改善绝经早期妇女生理、心理相关症状,明显提高生活质量。Objective： To explore the effect of low-dose hormone replacement therapy （HRT） on physiological and psychological health in women at early stage of menopause. Methods： Forty women at early stage of menopause who had clinical symptoms of menopause and psychological symptoms were orally administered 0.3 mg/d of premarin and 2 mg/d of medroxyprogestemne acetate for 6 months,and calcium was given simultaneously. The clinical symptoms and the average scores of Symptom Checklist 90 （SCL-90） before and after the treatment were compared. The relationship between clinical and psychological symptoms was analyzed. Results： The clinical symptoms and the average scores of SCL-90 were signitleantly improved after low-dose HRT. The clinical symptoms of menopause was correlated with the psychological symptoms, Conclusion： Low-dose HRT could improve the physiological and psychological status and the living quality of women at early stage of menopause.

关 键 词：绝经早期 生理健康 心理健康 激素替代治疗 

分 类 号：R711[医药卫生—妇产科学]