R5 to X4 coreceptor switch of human immunodeficiency virus type 1B' and B'/C recombinant subtype isolates in China  

作　　者：GUO Yan-fang MA Li-ying YUAN Lin WANG Shu-hua SUN Jian-ping XU Wei-si Xu Jian-qing XING Hui HONG Kun-xue ZHANG Xiao-yan RUAN Yu-hua ZHANG Yao-xin SHAO Yi-ming 

机构地区：[1]State Key Laboratory for Infection Diseases Prevention and Control, National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 100050, China [2]Xinjiang Medical University, Urumqi 830054, China

出　　处：《Chinese Medical Journal》2007年第6期522-525,共4页中华医学杂志（英文版）

基　　金：This study was supported by the grants from the Ministry of Science and Technology of People's Republic of China(No.2005CB523103 and No.2005CB522903);the US NIH grants(No.U19AIS1915-03)

摘　　要：The chemokine receptors CCR5 and CXCR4 play an important role as coreceptors for human immunodeficiency virus type 1 （HIV-1） entring into cells. HIV-1 isolates can be distinguished by the chemokine coreceptors. Nonsyncytium inducing （NSI）, macrophage tropic viruses utilizing CCR5, are called R5 viruses; syncytium inducing （SI） isolates use CXCR4 and known as X4 viruses. R5 viruses generally are associated with latent stage of infection and X4 viruses with later,The chemokine receptors CCR5 and CXCR4 play an important role as coreceptors for human immunodeficiency virus type 1 （HIV-1） entring into cells. HIV-1 isolates can be distinguished by the chemokine coreceptors. Nonsyncytium inducing （NSI）, macrophage tropic viruses utilizing CCR5, are called R5 viruses; syncytium inducing （SI） isolates use CXCR4 and known as X4 viruses. R5 viruses generally are associated with latent stage of infection and X4 viruses with later,

关 键 词：HIV-1 B ＇/C recombinant viruses subtype B＇ coreceptor switch 

分 类 号：R373[医药卫生—病原生物学]