影响动脉弹性功能的临床因素分析  

Clinical factors relating to the arterial elastic function measured by PWV,C1//C2 and AI in hypertensive patients

作　　者：蔡凯愉[1] 张维忠[1] 邱惠丽[1] 吴美枝[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市高血压研究所200025

出　　处：《中华心血管病杂志》2007年第3期237-240,共4页Chinese Journal of Cardiology

摘　　要：目的分析影响动脉弹性功能的临床因素及其共同点。方法对人选的2176例高血压患者分别采用不同的动脉弹性功能测定,以评价各种动脉弹性功能参数的临床影响因素。其中1100例测定脉搏波传导速度(PWV),647例测定大动脉弹性指数(C_1)和小动脉弹性指数(C_2),429例测定收缩期压力波增强指数(AI)。结果年龄、收缩压、脉压是 PWV 和 C_1的共同影响因素;年龄、收缩压是 C_1、C_2的共同影响因素。在高脂血症患者中年龄、TC 水平是 C_1、C_2的共同影响因素。AI 与 PWV、C_1、C_2之间缺乏共同影响因素。结论 (1)PWV 与 C_1、C_1与 C_2之间存在着一致性。(2)选择 PWV、C_1、C_2作为临床研究指标,尤其进行组问比较,可能更为合理。(3)AI 受操作熟练程度及生理因素影响较大,在采用 AI 进行临床研究时,必须充分考虑和估计这些因素的影响。Objective To analyze the clinical factors relating to arterial elastic function measured with pulse wave velocity （PWV） , large and small arterial elastic indexes （C1 and C2 ） and augmentation index （AI） in hypertensive patients. Methods A total of 2176 hypertensive patients were enrolled and divided into three groups：Elastic function was measured in 1100 subjects by（PWV） ,in 647 subjects by C1 and C2 and in 429 by AI. Results PWV was positively correlated with age, systolic pressure, pulse pressure and negatively correlated with body height and weights （ all P 〈 0. 05）. C1 and C2 values were higher in male than that in female patients （ P 〈0. 01 ） and negatively correlated with age, systolic pressure, pulse pressure and heart rate while positively correlated with body height, weight and body mass index. In hypercholesterolemia patients （n = 168）, C1 and C2 were negatively correlated with serum cholesterol level （P 〈 0. 05）. AI value was higher in female than that in male patients （ P 〈 0. 01 ） and positively correlated with age, systolic pressure, diastolic pressure, pulse pressure while negatively correlated with body height, weight and heart rate. Conclusion Age, systolic and pulse pressure as well as body height and weights are the main factors correlated to arterial elastic function measured by PWV, C1 and C2 and AI.

关 键 词：动脉 弹性 高血压 

分 类 号：R543[医药卫生—心血管疾病]