2种多西环素注射液在健康猪体内的药动学比较  

Comparision of Pharmacokinetics of Two Different Doxycycline Injections in Pigs

作　　者：杨海峰[1] 覃少华[1] 王加才[1] 王磊[1] 江善祥[1] 

机构地区：[1]南京农业大学动物医学院

出　　处：《华中农业大学学报》2007年第1期76-79,共4页Journal of Huazhong Agricultural University

基　　金：江苏省科技厅攻关项目(JH02-085)资助

摘　　要：选用6头健康仔猪,按随机交叉设计试验,进行肌注2种多西环素注射液(10 mg/kg)的药代动力学研究。用固相萃取-高效液相色谱法测定血浆中多西环素的浓度,所得药-时数据用3P97药动软件处理。普通多西环素注射液和长效多西环素注射液肌注给药的药-时数据均符合一级吸收二室开放模型,主要药动学参数如下:T1/2Ka(吸收半衰期)分别为(0.22±0.06)h和(0.51±0.17)h,T1/2β(消除半衰期)为(5.21±1.78)h和(11.07±4.14)h,Tmax(峰时)为(0.62±0.27)h和(2.31±0.44)h,Cmax(峰浓度)为(2.61±0.58)μg/mL和(1.24±0.33)μg/mL,AUC(药-时曲线下面积)为(9.53±2.47)μg.h/mL和(19.85±5.62)μg.h/mL。普通多西环素注射液肌注给药在健康猪体内的药动学特征为:吸收迅速,达峰快,体内分布广。长效注射液具有缓释和长效特征。Abstract A eomparision of pharmaeokineties was investigated in 6 healthy pigs following intramuscular administration of two different doxycycline injections at a single dose of 10 mg/kg. Doxycycline concentration in plasma was determined by a high performance liquid chromatography with solid phase extraction method. The concentration-time data were analyzed with 3P97 computer program. The concentration-time data were both fitted a two-compartment open model with first-order absorption after single intramuscular administration of common doxycycline injection and long-acting injection. The main pharmacokinetic parameters were as follows, respectively. T1/2Kα（0. 22±0. 06） h and （0. 51±0. 17） h, T1/2β（5. 21±1. 78） h and （11.07±4. 14） h,Tmax（0. 62±0.27） h and （2.31±0.44） h,Cmax（2. 61±0. 58） μg/mL and （1.24±0. 33） μg/mL,AUC （9. 53±2. 47） （μg · h/mL） and （19. 85±5. 62） μg · h/mL）. Doxycyline was absorbed fast and distributed extensively after intramuscular administration in healthy pigs. The long-acting formulation had a sustained and long-acting charater.

关 键 词：多西环素 药代动力学 固相萃取-高效液相色谱法 猪 

分 类 号：S859.796[农业科学—临床兽医学]