丙烯酸-Pluronic~ F127接枝共聚物的流变学性质  

Rheological evaluation of PAA-Pluronic~ F127 graft copolymers

作　　者：马文狄[1] 潘卫三[1] 徐晖[1] 聂淑芳[1] 张立婷[2] 郑俊民[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳富东制药有限公司,辽宁沈阳110041

出　　处：《沈阳药科大学学报》2007年第3期129-132,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究丙烯酸Pluronic F127接枝共聚物的流变学性质。方法用同轴圆筒流变仪测定共聚物溶液的流变参数。结果共聚物溶液在较低浓度下具有温度敏感的原位凝胶特性。结论丙烯酸-Pluronic F127接枝共聚物作为一种具有温度敏感原位凝胶性质的材料,具有广泛的应用前景。Objective To study the rheological behavior of PAA-Pluronic F127 graft copolymers. Methods Rheological parameters of the copolymers were measured by Physica MCR 300 co-axial cylinder rheometer. Results Compared to Pluronic F127, the copolymer solutions showed thermo-sensitively in situ forming gelling properties at relatively lower concentrations. Conclusions As a thermal-sensitive in situ forming gelling material, such copolymers show great potential for drug delivery systems.

关 键 词：丙烯酸 PLURONIC F127 共聚物 原位凝胶 流变学 

分 类 号：R94[医药卫生—药剂学]