逍遥散抗抑郁作用研究  

Studies on the anti-depression effect of Xiaoyao Powder(逍遥散) in mice

作　　者：熊静悦[1] 曾南[1] 张崇燕[1] 杨婧[1] 刘晓帅[1] 

机构地区：[1]成都中医药大学药学院,成都611731

出　　处：《中药药理与临床》2007年第1期3-5,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：成都中医药大学校基金重点项目资助;编号:ZRZD200503

摘　　要：目的:探讨逍遥散的抗抑郁作用及机制,为其疏肝解郁功效及临床应用提供药理学参考。方法:采用小鼠悬尾实验和小鼠强迫游泳实验观察逍遥散的抗抑郁作用,采用开场实验观察逍遥散对小鼠自主活动的影响;采用5-HTP、DOI致小鼠甩头实验探讨逍遥散抗抑郁作用的机制。结果:逍遥散7.8、15.6g/kg剂量连续给药7d能明显缩短悬尾实验中小鼠的不动时间,15.6g/kg剂量连续给药7d能明显缩短强迫游泳实验中小鼠的不动时间,各有效剂量对小鼠自主活动无影响;逍遥散31.2g/kg剂量连续给药7天能显著减少5-HTP所致小鼠甩头次数,但对DOI诱导的小鼠甩头反应无明显影响;逍遥散31.2g/kg剂量单次给药能明显减少由5-HTP、DOI诱导的小鼠甩头次数;逍遥散15.6g/kg剂量单次给药亦能显著减少由5-HTP诱导的小鼠甩头次数。结论:逍遥散具有抗抑郁作用,作用机制可能与影响脑内5-HT能神经系统有关,特别是5-HT2A受体的功能。Objective： To investigate the anti-depression effect and the possible mechanism of Xiaoyao Powder in several animal models. Method： The tail suspension test （TST） and the forced swimming test （FST） were applied to study the anti- depression effect of Xiaoyao Powder in mice. The open-field test was carried out to observe the effect of Xiaoyao Powder on automatic activities in mice. The possible mechanism of its anti- depression effect was studied by 5-HTP or DOI induced head-twitch-response （HTR） in mice. Result： The immobility time of TST was significantly decreased by the dose of 7.8,15.6g/kg of Xiaoyao Powder （ P 〈0.01 ）, as well as the immobility time of FST was significantly decreased by the dose of 15.6g/kg of Xiaoyao Powder（ P 〈0.01 ） following treatment for 7d continuously in mice. Xiaoyao Powder had no effect on the automatic activities in the open field test in mice at the dose of 7.8,15.6g/kg. The times of 5-HTP induced HTR were significantly decreased by the dose of 31.2g/kg of Xiaoyao Powder following treatment for 7d continuously in mice（ P 〈 0.05 ） , but had no effect on DOI induced HTR. The times of 5-HTP and DOI induced HTR were significantly decreased by the dose of 31.2g/kg of Xiaoyao Powder single treatment in mice （ P 〈 0.01, P 〈 0.05） , as well as the times of 5-HTP induced HTR were also significantly decreased by the dose of 15. 6g/kg of Xiaoyao Powder single treatment in mice （ P 〈 0.01 ）. conclusion： The resuhs suggest that Xiaoyao Powder has the anti-depression effect, which the mechanism could be related to affect the 5-HT nervous system, especially the 5-HT2A receptor.

关 键 词：逍遥散 抗抑郁 5-HT 活动 

分 类 号：R285.5[医药卫生—中药学]