僵蚕抗凝成分ACIBB对实验性静脉血栓形成的影响  

Effect of anticoagulant components in Bombys Batryticatus on thrombosis

作　　者：彭延古[1] 雷田香[1] 付灿云[1] 曾序求[1] 李路丹[1] 

机构地区：[1]湖南中医药大学,长沙410007

出　　处：《中药药理与临床》2007年第1期27-29,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究僵蚕抗凝成分(ACIBB)对大鼠实验性静脉血栓形成的影响。方法:采用结扎大鼠腹主静脉造成静脉血栓模型,观察ACIBB对纤溶、凝血系统的影响。结果:ACIBB可明显抑制大鼠实验性静脉血栓的形成,抑制纤维蛋白原含量(Fbg)、纤溶酶原含量(Plg),增强tPA与AT-Ⅲ的活性,抑制PAI活性,并明显延长激活部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)。结论:ACIBB通过降低内、外源凝血系统因子的活性,增加纤溶系统活性,进而防止血栓的形成。Objective： To investigate the effect of anticoagulant components in bombys batryticatus （ACIBB） on venous thrombosis in rabbits. Methods ： The effects of ACIBB in different doses were investigated in the venous thrombus models by ligated the abdomial vena of rabbits. Results： The ACIBB could inhibit experimental venous thrombosis in rabbits, decrease the content of fibrinogen （Fbg）and plasminogen （PLg） ,so that increase the activity of tissue-tye plasminogen activater （tPA） and antithrombin Ⅲ （AT- Ⅲ）, inhibit the activity of plasminogen activator inhibitor （PAI）. Meanwhile, the activated partial thromboplastin time （APTT）, prothrombin time （PT） and throbmin time （TT） were prolonged obviously. All results held significant meaning than experimental controlling group. Conclusions： ACIBB increases the activity of fibinolytic system through decreased the activity of blood coagulating factors, so that inhibits thrombosis.

关 键 词：僵蚕 抗凝成分 抗血栓 实验 

分 类 号：R285.5[医药卫生—中药学]