互花米草内生真菌Fusarium sp.F4中的活性代谢物  

Metabolites of Endophytic Fungus Fusarium sp.F4 from Spartina alterniflora

作　　者：邵志宇[1] 冯永红[2] 邓云霞[1] 徐德强[3] 洪枫[1] 

机构地区：[1]东华大学生物科学与技术研究所,上海201620 [2]上海市结核重点实验室,上海200433 [3]复旦大学生命科学院,上海200433

出　　处：《中国天然药物》2007年第2期108-111,共4页

基　　金：东华大学学校基金(620-08-007610)~~

摘　　要：目的:研究海草Spartina alterniflora中内生真菌Fusarium sp.F4中的活性代谢物。方法:经硅胶、Sephadex LH-20反复柱层析分离纯化并通过波谱分析鉴定了6个化合物。结果:6个化合物分别被鉴定为麦角甾醇(Ⅰ)、过氧化麦角甾醇(Ⅱ)、白僵菌素(Ⅲ),T-2毒素(Ⅳ),ilicicolin H(Ⅴ),alcaligin(Ⅵ)。结论:化合物Ⅴ、Ⅵ为首次从该属真菌中发现。全归属了化合物V的氢谱数据。药理实验表明化合物III对结核分枝杆菌毒株(Mycorbacterium tuberculosis H37RV)有显著抑制。AIM： To study the metabolites of endophytic fungus Fusarium sp. F4, which was isolated from seagrass Spartina altemiflora. METHOD： Compounds were isolated by column chromatography （silica gel, Sephadex LH-20） and their structures were elucidated by spectroscopic analysis. RESULTS： Six compounds were obtained and identified as ergosterol （ Ⅰ ）, ergosterol peroxide （ Ⅱ ）, beauvericin （ Ⅲ ）, T-2 toxin（ Ⅳ ）, ilicicolin H（ Ⅴ ） and alcaligin （Ⅵ ）. CONCLUSION. Compounds V and Ⅵ were obtained from Genus Fusarium for the first time. ^1H NMR data of V were total assignmented based on ^1H-^1H COSY and HMBC. Compound Ⅲ showed significant inhibition to Mycorbacterium tuberculosis H37RV.

关 键 词：FUSARIUM sp. 代谢物 药理活性 

分 类 号：R282.77[医药卫生—中药学]