新型小肽偶联物的合成及对T淋巴细胞增殖的影响  

Synthesis of Novel Small Peptide Coupling Compounds and Their Activity to Induce T Lymph Cell Proliferation

作　　者：刘艺[1] 张奕华[1] 

机构地区：[1]中国药科大学新药研究中心,南京210009

出　　处：《中国天然药物》2007年第2期115-119,共5页

摘　　要：目的:合成新型小肽偶联物,寻找具有抗肿瘤活性及肝靶向性的新化合物。方法:以齐墩果酸和胆酸为母核,分别与活性小肽偶联,考察此类偶联物对T淋巴细胞增殖的影响。结果与结论:合成了8个新型小肽偶联物(Z1～Z8),其结构经IR,1HNMR和MS确证。初步药理结果表明,目标物Z1、Z2、Z4、Z8可不同程度地促进T淋巴细胞增殖,与对照药酪丝亮肽相比有显著性差异,其中化合物Z4最优,具有进一步研究的价值。AIM： To synthesize novel small poptide coupling derivatives with high anti-cancer activity and liver-targeting pmporty. METHODS： Oleanolic acid and cholic acid were coupled with active small poptides; the activity of the coupling compounds to induce T lymph cell proliferation was studied. RESULTS AND CONCLUSION： Eight small poptide coupling compounds（Z1-Z8） were obtained and their structures were confirmed by IR, ^1H NMR and MS. Compounds 1, 2,4 and 8 showed higher activity than the control YSL in inducing lymph cell proliferation. Compound Z4 was the most active one deserving further investigation.

关 键 词：齐墩果酸 胆酸 小肽 合成 

分 类 号：R284.3[医药卫生—中药学]