腰痛灵栓治疗椎间盘突出与活血化瘀的关系  

Curative effect of Lumbago Suppository on prolaps of intervertebral disc in rat

作　　者：李涓[1] 罗才贵[1] 谢子清[1] 唐熠[1] 

机构地区：[1]成都中医药大学附属医院,四川成都610072

出　　处：《中成药》2007年第3期338-342,共5页Chinese Traditional Patent Medicine

基　　金：四川省科技厅资助课题(S-5)

摘　　要：目的:观察腰痛灵栓(川乌、桂枝、麝香等)对椎间盘突出的抗炎、镇痛与活血化瘀的关系。方法:建立大鼠化学神经根炎模型,观察腰痛灵栓对炎症、痛阈、步态和血清中磷脂酶A2(PLA2)、肾上腺素、去甲肾上腺素含量的影响;采用大鼠寒凝型血瘀证模型观察其对血液流变性的影响;用小鼠耳廓微循环法观察其对微循环的作用。结果:腰痛灵栓剂对大鼠神经根炎模型的炎症有显著的抑制作用、对其步态和痛阈有明显恢复作用,能显著降低血清中磷脂酶A2(PLA2)的含量,对肾上腺素、去甲肾上腺素的水平有升高趋势;能显著改善“血瘀”大鼠的血液流变性,显著改善小鼠耳廓微循环。结论:腰痛灵栓的抗炎、镇痛作用与活血化瘀作用密切相关。AIM： According to the functions of Lumbago Suppositiory （Radix Aconiti, Ramulus Cinnamoni, Moschus, etc） （LS） , we observed the connection among anti-inflammatory, analgesia and promoting blood circulation and removing blood stasis. METHODS： Rat chemical radiculoneuritis model was set up to observe influence of LS on inflammation, pain threshold, gait and PLA2 in serum, content of adrencorticoids and adrenalin. Cold accumulation type of blood stasis symptom model was built up to observe the influence of LS on blood rheological property, effect of LS on mouse＇s micr-coirculation in ears was also observed. RESULTS： Lumbago Suppository inhibited inflammation of rat radiculoneuritis model obviously and had recovery of functions for gait and pain threshold. And it also could reduce the content of PLA2 in serum and raise the level of adrenocorticoids and adrenalin. It also obviously changed ＂blood stasis symptom＂, rat blood rheological property and auricle micro-circulation of mouse. CONCLUSION： Lumbago Suppository＇s functions of anti-inflammatory and analgesia have strong relation ships with promoting blood circulation and removing blood stasis.

关 键 词：腰痛灵栓 抗炎镇痛 活血化瘀 动物试验 

分 类 号：R285.6[医药卫生—中药学]