补骨脂素乳膏与凝胶体外释放与透皮吸收的比较研究  

Comparison of the release and percutaneous penetration in vitro between psoralen ointment and gel

作　　者：黄芳芳[1] 杨得坡[1] 梁淑明[1] 

机构地区：[1]中山大学药学院生药学与天然药物化学实验室,广东广州510080

出　　处：《中成药》2007年第3期349-351,共3页Chinese Traditional Patent Medicine

基　　金：广州市科技局对外科技合作项目(穗条科字(2003)51号)

摘　　要：目的:比较2种补骨脂素乳膏与补骨脂凝胶体外释放和透皮吸收的特点。方法:分别采用溶出试验仪和Franz扩散池法进行体外释放和透皮吸收实验,并用高效液相色谱法测定释放液、接收液和皮肤中补骨脂素的含量。结果:三种制剂的体外释放和体外透皮均符合零级动力学方程,2种乳膏释放速率无差别;皮肤中补骨脂素的滞留量无显著性差异。结论:补骨脂素凝胶的体外透皮效果优于乳膏。AIM： To compare the release and percutaneous penetration in vitro among 2 kinds of the psoralen ointments and its gel. METHODS： Dissolution tester and Franz diffusion cells were adopted as the release and percutaneous penetration in vitro, and HPLC was used to measure the amount of psoralen in the releasing solution, receiving solution and the skin. RESULTS ： The release and percutaneous penetration of psoralen from the 3 kinds of preparation conformed to the zero kinetic equation. The steady-state penetration rate of psoralen in the gel was higher than that of the ointment, and there was no significant difference between 2 kinds of ointments. CONCLUSION：Gel is a better choice for percutaneous penetration of psoralen.

关 键 词：补骨脂素 乳膏 凝胶 体外释放 透皮吸收 

分 类 号：R944[医药卫生—药剂学]