新生儿缺氧缺血性脑病脑干诱发电位与脑地形图/脑电图相关性研究  

The Relativity Study of BAEP and BEAM/EEG in Newborn Hypoxia-Ischemic Encephalopathy

作　　者：何冬若[1] 张英慧[1] 孙伟[1] 

机构地区：[1]黑龙江省齐齐哈尔医学院第二附属医院,161006

出　　处：《医学研究杂志》2007年第3期36-38,共3页Journal of Medical Research

基　　金：黑龙江省齐齐哈尔市科技局指导性研究项目(2003年)

摘　　要：目的研究脑干诱发电位(BAEP)与脑地形图/脑电图(BEAM/EEG)对新生儿缺氧缺血性脑病(HIE)诊断的特殊价值、两者相关性及与HIE后遗症的关系,以其评价临床疗效和预后的评估。为患儿寻找最佳治疗时间,降低后遗症的发生。方法采用16道脑地形图仪和肌电诱发电位仪分别对HIE患儿于初诊治疗前、30天、3个月、6个月、12个月、24个月进行BA-EP、BEAM/EEG同步检测。结果BAEP、BEAM/EEG对HIE的神经细胞功能的康复具有特殊的诊断价值,尤其以恢复期的检测意义更为重要。研究发现恢复期两者呈非同步状态,BAEP恢复晚于BEAM/EEG,重度HIE,BAEP恢复缓慢者预后差,对后遗症的评定BAEP的指标较BEAM/EEG敏感。结论单纯BEAM/EEG损伤者,提示HIE患儿仅局限皮层损伤,预后良好,BAEP损伤者说明HIE患儿同时存在脑干神经细胞毒性损伤,且重度异常者预后差。BAEP、BEAM/EEG两者结合应用于临床,从电生理学不同角度研究HIE神经细胞元的恢复程度,对完善HIE的治疗有着重要的价值。Objective Study the special value of the brainstem auditory evoked potential （BAEP） and Brain Geography Diagram （BEAM/EEG） for diagnosis of Newborn HypoxicIschemic Encephalopathy （HIE） ,the correlation between BAEP, BEAM/EEG and HIG,and the relation with HIE linger effect, so as to evaluate clinical curative effect ,find out the best treatment time, lower the occurrence of linger effect . Methods the BEAM/EEG and BAEP were detected synehronously by adopting 16 traots of BEAM/EEG and BAEP instruments for HIE before treatment, at thirtieth day, the third Month ,the sixth Month, the twelfth Month and the twenty - fourth Month respectively. Results The BAEP, BEAM/EEG have special diagnostic value on nerve cell function recovery, examination of recovery period in particalar. The research discovers the both are not synehronous in recovery period, the BAEP recovers is later than BEAM/EEG;for heavy degree HIE,BAEP recovering is slow with bad therapy effect, BAEP index sign is more sensitive to BEAM/EEG to assess linger effect . Conclusions Simple BEAM/EEG damaye indicates the brain cortex iniury only, so the prognosis is good;while BAEP damage suggestes the patiemts have brain stem nerve cell injury simultaneously, with bad prognosis for the heavy degree abnormality, in combination with BAEP and BEAM/EEG in clinical practiae, investigation of recovery degree of HIE herve cells by kinds of electric physiology angles it would have important value to perfect the treatment of HIE.

关 键 词：新生儿缺氧缺血性脑病(HIE) 脑干听觉诱发电位(BAEP) 脑电地形图/脑电图(BEAM/EEG) 

分 类 号：R722.12[医药卫生—儿科]