姜黄素脂质体在大鼠体内药代动力学研究  

Study On Pharmacokinetics of the Curcumin Liposomes in Rat

作　　者：许汉林[1] 孙芸[2] 邵继征[1] 熊利容[1] 张念[1] 黄成刚[1] 

机构地区：[1]湖北中医学院药学院,湖北武汉430065 [2]新疆医科大学医药学院,新疆乌鲁木齐830054

出　　处：《湖北中医学院学报》2007年第1期42-43,共2页Journal of Hubei College of Traditional Chinese Medicine

基　　金：湖北省自然科学基金项目;[2006ABA062]

摘　　要：目的研究姜黄素脂质体口服液在大鼠体内的药代动力学行为。并与游离姜黄素溶液进行比较,评价姜黄素脂质体药代动力学特征。方法大鼠灌胃给药,摘眼球取血,HPLC测定血药浓度;采用3P87药代软件模拟房室模型并计算药代动力学参数。结果当姜黄素的给药量1次接近300 mg/kg时,其药代动力学过程为非线性动力学过程。结论姜黄素脂质体口服液比姜黄素混悬液入血速度明显加快,有利于机体的吸收,并且消除减慢,血液中浓度高,在组织中分布广。Objective： To study the concentration of the curcumin liposomes oral liquid in rat with time changed in comparision of the free curcumin suspension, and then estimate the pharmacokinetic characteristics of the curcumin liposomes. Methods： Drawing the blood from eyeball of rat after oral administration and the blood concentrations were determined by HPLC. Simulating compartment model with software program 3P87 and calculating pharmacokinetics parameters. Results： The pharmacokinetic characteristics were nonlinear when curcumin was 60mg each tima Conclusion： Curcumin liposomes oral liquid is absorbed more rapidly and eliminated more slowly than curcumin suspension, which is also distributed in more tissues and the concentrations in blood is higher.

关 键 词：姜黄素 姜黄素脂质体 药代动力学 

分 类 号：R285[医药卫生—中药学]