丙型肝炎患者血清IGF-Ⅱ水平与脂质过氧化物的相关研究  

Study of the relationship between the serum insulin-like growth factor Ⅱ(IGF-Ⅱ)and lipid peroxidation levels in patients with hepatitis C.

作　　者：吴友山[1] 

机构地区：[1]江苏省连云港市第一人民医院东方医院消化科,222042

出　　处：《淮海医药》2007年第2期105-106,共2页Journal of Huaihai Medicine

摘　　要：目的探讨丙型肝炎患者血清IGF-Ⅱ水平与脂质过氧化物的关系。方法应用放免法测定胰岛素样生长因子Ⅱ(IGF-Ⅱ)水平,化学法测定血浆丙二醛(M DA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与35名正常人作对照。结果62例丙型肝炎患者血清IGF-Ⅱ、M DA水平高于对照组(P<0.01),而SOD、GSH-PX水平低于对照组(P<0.01),相关分析显示:丙型肝炎患者血清IGF-Ⅱ水平与M DA呈正相关(r=0.6014,P<0.01)。结论丙型肝炎患者血清IGF-Ⅱ水平的升高与活性氧代谢紊乱有关。Objective To study the relationship between the serum IGF- Ⅱand lipid peroxidation levels in patients with hepatitis C. Methods Serum IGF- Ⅱ levels were measured with RIA. Plasma MDA,SOD and GSH-PX levels were measured with chemocolorimetry in 62 patients with hepatitis C as well as in 35 controls. Results serum IGF-Ⅱ and MDA levels were significantly higher in the patients than those in the controls （P〈0.01）. Correlation analysis showed that serum IGF- Ⅱlevels were positively correlated （r=0. 6014,P〈0.01）. Conclusion The higher IGF- Ⅱlevels were closely associated with the lipid peroxidation disturbance in patients with hepatitis C.

关 键 词：肝炎 丙型 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 胰岛素样生长因子Ⅱ 

分 类 号：R512.63[医药卫生—内科学] R446[医药卫生—临床医学]