脂蛋白脂酶及其基因多态性与血管危险因素  

Lipoprotein Lipase and Its Genetic Polymorphism and Vascular Risk Factors

作　　者：尹晶[1] 李震中[1] 

机构地区：[1]河北医科大学附属第二医院神经内科,石家庄050000

出　　处：《国际脑血管病杂志》2007年第2期97-101,共5页International Journal of Cerebrovascular Diseases

摘　　要：脂蛋白脂酶（LPL）及其基因多态性已成为近年来研究的热点。LPL具有脂解作用和分子桥作用，其在不同位点的基因多态性（如HindⅢ、PvuⅡ、S447X、-93T→G、D9N、N291S、Gly188Glu、D8S261等）对血脂、血糖和血压水平等有一定的影响，与动脉粥样硬化和心脑血管病也存在一定的相关性。文章对LPL基因多态性与血管危险因素的关系进行了综述。Lipoprotein lipase （LPL） and its genetic polymorphism have become a topic of general interest in recent years. LPL has the lipolysis and molecular bridge effects. Its genetic polymorphisms （such as Hind Ⅲ, Pvu Ⅱ, S447X, -93T→G, D9N, N291S, Gly188Glu, and D8S261） on different genetic loci have certain effects on blood lipids, blood glucose and blood pressure levels, and it also has a certain correlation with atherosclerosis and cardio-cerebrovascular diseases. This article reviews the relationship between LPL genetic polymorphism and vascular risk factors.

关 键 词：脂蛋白脂酶 基因多态性 动脉粥样硬化 冠状动脉疾病 脑血管疾病 

分 类 号：R54[医药卫生—心血管疾病]