Others——Single nudeotide polymorphism of calcitonin receptor gene and idiopathic hypercalciuria  

作　　者：杨奕 

机构地区：[1]Dept Surg,School Onool,Peking Univ,Beijing Cancer Hosp,Beijing 100036

出　　处：《China Medical Abstracts》2007年第1期59-59,共1页中国医学文摘（外科学分册英文版）

摘　　要：Objective To explore the association of the calcitonin receptor （CTR） allelic polymorphism in the 1 377 bp region with the risk of idiopathic hypercalciuria （IH） in the Han nationality in Hubei area, and to study the pathogenesis of IH. Methods The CTR genotypes were determined by polymerase chain reaction-restriction flagment length polymorphism in 76 patients with IH and 126 healthy controls from the Han nationality in Hubei area, using restriction endonuclease AluI. Results The distri bution frequencies of AluI alleles in the 2 groups followed the Hardy-Weinberg equilibrium. The distribution frequencies of the CC, TC and TT genotypes were 73.7%, 17.1% and 9.2% in IH patient group, and 89.7%, 9.5 % and 0.8 % in control group; the distribution frequencies of C and T alleles in the 2 groups were 84.2 %, 15.8 % and 94.4 %, 5.6 %, respectively. The distribution frequencies of T and TT alleles were higher, while those of C and CC alleles were lower, compared with control group;the differences between the 2 groups were significant （P 〈 0.05）. Conclusion The results indicate that the C/T single nucleotide polymorphism in the CTR gene play a significant role in the mechanism of IH in the Han nationality in Hubei area in China. 7 refs,2 figs,2 tabs.

关 键 词：基因多态性 降血钙素 高钙尿症 病理机制 

分 类 号：R695[医药卫生—泌尿科学]