脾阳虚证大鼠肝组织中端粒长度变化的实验研究  

Experimental Study on the Change of Telomere Length in the Liver of Rat Model with Spleen Yang Deficiency syndrome

作　　者：秦建设[1] 崔家鹏[2] 王彩霞[2] 吕爱平[2] 王伯庆[2] 

机构地区：[1]辽宁中医药大学 [2]辽宁中医药大学中医基础教研室,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2007年第2期143-144,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30171125)

摘　　要：目的:探讨脾阳虚状态下肝细胞端粒长度的变化。方法:采用经典复合造模法塑造脾阳虚证动物模型;测定肝组织中谷胱甘肽过氧化物酶(GSH-PX)活性和肝细胞端粒长度。结果:与正常对照组相比,脾阳虚证的肝组织中的谷胱甘肽过氧化物酶(GSH-PX)活性明显降低(P<0.01),肝细胞端粒长度显著缩短(P<0.01)。结论:在脾阳虚状态下,肝细胞端粒长度缩短可能与自由基损伤有关。Objective： To observe the change of telomere length in the liver with spleen Yang deficiency syndrome. Methods： The rat model of spleen Yang deficiency syndrome was established by the classical composite factors. The activity of the GSH-PX and telomere length were determined in the liver. Result： Compare with the normal control, the activity of GSH-PX in the liver of rat model with spleen Yang deficiency syndrome was lower and telomere length was shorten. Conclusion： The shortening of telomere length may be related to the free radicals damage with spleen Yang deficiency syndrome.

关 键 词：脾阳虚证 自由基 端粒长度 GSH-PX 

分 类 号：R285.5[医药卫生—中药学]