HLA-DRB1等位基因多态性与白血病易感性关联的研究  

Association between HLA-DRB1 alleles polymorphism and susceptibility to leukemia

作　　者：周兰霞[1] 赵丽[1] 

机构地区：[1]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2007年第1期34-36,共3页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金暨中青年基金(YS001-A23-020)资助项目。

摘　　要：目的探讨白血病易感性与HLA-DRB1基因多态性之间的相关性,寻找白血病的易感基因。方法采用聚合酶链反应和序列特异性寡核苷酸探针杂交技术对65例白血病患者和48例健康对照者进行HLA-DRB1基因分型。结果在等位基因HLA-DRB1中共出现16个位点,DR11等位基因在白血病患者的频率明显高于正常对照者(P＜0．05),其他等位基因在两者之间差异无统计学意义。结论基因DR11对白血病有遗传易感作用。Objective In order to explore the association between HLA-DRB1 allele polymorphism and susceptibility to leukemia and find the susceptible genes of leukemia. Methods HLA- DRB 1 allele polymorphism in 65 patients with leukemia and 48 normal subjects was determined by PCR with sequence specific oligonucleotide probe. Results The allele frequencies of HLA-DR11 in leukemia patients were increased when compared with normal controls （P 〈0.05）. Conclusion HLA-DR11 alleles seem to have genetic susceptibility to leukemia.

关 键 词：人类白细胞抗原 白血病 聚合酶链反应 基因多态性 

分 类 号：R392.12[医药卫生—免疫学]