梗阻性黄疸凝血障碍与血管内皮细胞损伤的关系  

Relationship between dysfunction of blood coagulation and endothelial cell injury in obstructive jaundice

作　　者：张玉怀[1] 寇治民[1] 张有成[1] 

机构地区：[1]兰州大学第二医院普通外科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2007年第1期79-83,共5页Journal of Lanzhou University（Medical Sciences）

摘　　要：采用文献回顾的方法对梗阻性黄疸致血管内皮细胞损伤的因素及发生凝血障碍的机理进行综述,探讨梗阻性黄疸致血管内皮细胞损伤的因素及发生凝血障碍的机理。梗阻性黄疸时损伤内皮细胞的因素有内毒素、胆红素、胆汁酸盐、高血脂、手术创伤和肿瘤等,梗阻性黄疸时血管内皮细胞促凝功能与抗凝功能均发生改变。多因素致梗阻性黄疸时血管内皮细胞损伤,梗阻性黄疸时存在的凝血机制紊乱与血管内皮细胞的损伤有密切关系。The factors that induce endothelial cell injury and dysfunction of blood coagulation in obstructive jaundice were reviewed to investigate the factors that induce endothelial cell injury and dysfunction of blood coagulation in obstructive jaundice. The factors that induce endothelial cell injury are endotoxin, bilirubin, bile acid, hyperlipemia, operation and tumor in obstructive jaundice. Meanwhile, both the coagulation and anticoagulation are changing. Various factors induce endothelial cell injury in obstructive jaundice. There is a closing relationship between dysfunction of blood coagulation and endothelial cell injury in obstructive jaundice.

关 键 词：梗阻性黄疸 血管内皮细胞 凝血 

分 类 号：R657.43[医药卫生—外科学]