老年急性冠脉综合征外周T淋巴细胞亚群水平变化研究  

Study on variation of T-lymphocyte subpopulations in blood of senior citizen with acute coronary syndromes

作　　者：唐剑 张康 莫丕立 叶少武 黎志革 陈永雄 陆兆华 彭晓燕 陀健琳 

机构地区：[1]广西梧州市人民医院,梧州市543000

出　　处：《广西医学》2007年第2期170-172,共3页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划课题资助项目(桂科攻0472002-20)

摘　　要：目的探讨老年急性冠脉综合征(ACS)患者血外周血T淋巴细胞亚群水平变化与发病关系。方法采用SAP法分别测定28例老年ACS患者、34例老年对照组(NC)的外周血T淋巴细胞亚群水平。结果ACS组CD 3+、CD 4+、CD 4+/CD 8+比值低于NC组(P<0.001),而CD 8+则高于NC组(P<0.001)。结论老年ACS患者存在细胞免疫功能紊乱,可能对老年ACS的形成和发展产生了影响。T淋巴细胞亚群比值变化可作为老年ACS严重程度的监测指标,免疫干预可能成为防治老年ACS的新途径。Objective To evaluate the level of T-lymphocyte subpopulations in blood of senior citizen with acute coronary syndromes （ACS） when the disease occurred. Methods The level of T-lymphocyte subpopulations in blood was assayed by SAP method from 28 senior citizens with ACS,34 cases normal controls（NC）. Result The level of CD 3 ＋ ,CD 4 ＋ and the ratio of CD 4 ＋/CD 8 ＋ in group ACS was less than that in group NC （P 〈 0.001 ）. But the level of CD 8 ＋ was more than that in group NC （ P 〈 0.001 ）. Conclusion The immune adjustment in senior citizen with ACS is unbalance. It will have an effect on forming and progress of ACS. The ratio of T-lymphocyte subpopulations in blood can be the measure to detect the serious degree of ACS severity. The intervention of immunity may to be the new method to prevent and cure the ACS.

关 键 词：急性冠脉综合征 老年人 T淋巴细胞亚群 SAP法 

分 类 号：R541.4[医药卫生—心血管疾病]