血管紧张素原基因多态性与肥厚型心肌病的相关性分析  

The Association study between angiotensinogen gene variation and hypertrophic cardiomyopathy

作　　者：王建伟[1] 王曙霞[1] 邹玉宝[1] 陈敬洲[1] 惠汝太 

机构地区：[1]中国医学科学院阜外心血管病医院中-德分子医学研究室,北京100037

出　　处：《临床内科杂志》2007年第3期200-202,共3页Journal of Clinical Internal Medicine

基　　金：北京市自然科学基金委员会资助;2004年重大项目(704001)

摘　　要：目的探讨血管紧张素原(AGT)基因的单核苷酸多态性(SNP)位点A943580G与肥厚型心肌病(HCM)的相关性。方法用PCR-RFLP方法对225个HCM病人和243个正常人的AGT的SNP位点A943580G进行基因分型(此位点与黑色人种中的高血压病人的最大早期充盈速度有关)。结果携带AA和AG基因型的HCM病人的左心室流出道梗阻率明显高于GG基因型的梗阻率(30.1%比17.0%,P<0.05)。通过对发病年龄,性别,室间隔厚度,HCM家族史以及家族猝死史进行调整后,携带A等位基因(AA+AG)的HCM病人左心室流出道梗阻率要高于GG基因型病人(OR=2.4,95%CI1.2to4.8)。结论AGT的A等位基因可能是HCM病人发生左心室流出道梗阻的危险因子。Objective To investigate the relationship between hypertrophic cardiomyopathy and angiotensinogen gene variation. Methods We genotyped the polymorphism of AGT gene in 225 HCM patients and 243 age-and sex-matched healthy controls. PCR-RFLP is used to genotype. Results The patients carrying A allele had a higher proportion of left ventricular outflow obstruction （30.1% versus 17. 0%, P 〈 0.05） than those carrying GG genotype. After adjusted for age at diagnosis, sex, interventricular septum, family history of HCM and family history of sudden death by using multiple regression analysis, the A allele confers 2.4 fold risk for left ventricular outflow obstruction than GG genotype （ adjusted OR = 2. 4,95% CI 1.2 to 4.8）. Conclusion A allele of AGT might be a genetic contributor for patients with HCM to develop left ventricular outflow obstruction.

关 键 词：肥厚型心肌病 修饰基因 左心室流出道梗阻 血管紧张素原 

分 类 号：R542.2[医药卫生—心血管疾病]