饮茶型氟骨症患者发和尿中9种元素水平分析  

Element concentrations in hair and urine of brick tea type skeletal fluorosis patients

作　　者：李海蓉[1] 赵晓宇[2] 刘庆斌 刘学慧 王五一[1] 李海龙[1] 李树海 王革 王丽珍[1] 冯福建[1] 

机构地区：[1]中国科学院地理科学与资源研究所地表环境化学与健康研究室,北京100101 [2]中国科学院研究生院 [3]内蒙古呼伦贝尔市地方病防治研究所地病科

出　　处：《中国地方病学杂志》2007年第2期200-202,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金资助项目（40471008）志谢 内蒙古呼伦贝尔市地方病防治研究所王在君、英殿双、周明仁、璋显坤、潘晶岩,陈巴尔虎旗卫生防疫站宝泉、郭巴特尔.鄂温克族自治旗地方病防治研究所于爱民等同志参加野外考察采样和临床普查工作,在此一并感谢

摘　　要：目的了解饮茶型氟骨症患者发、尿中氟、铝、钙、镁、磷、铜、锌、铁、锰9种元素水平。方法在内蒙古饮茶型氟中毒病区陈巴尔虎旗和鄂温克旗，共选择氟骨症患者73人及对照（不饮砖茶的汉族居民）64人，采集发样、尿样。用氟离子选择电极法和时序式电感耦合等离子体发射光谱仪（ICP-AES）分别测定样品中9种元素水平。利用Stat6．0软件，对分析结果进行正态分布检验和Kruskal-Wallis非参数差异性检验。结果饮茶型氟骨症组发铝、发铁、发磷及尿锰水平呈正态分布，对照组发铝、发磷、尿氟及尿铝水平呈正态分布，而两组发、尿中其他元素均为偏态分布。Kruskal-Wallis方差分析和中位数检验结果表明，饮茶型氟骨症组发铝、发锰、尿氟、尿铝、尿钙水平显著高于对照组（P〈0．05），而发锌、尿磷水平明显低于对照组（P〈0．05）。结论饮茶型氟骨症患者发、尿中铝、锰、锌、钙、磷元素存在代谢紊乱，其中铝、锰、锌等元素在饮茶型氟中毒病情发展中的作用需进一步深入研究。Objective To study the metabolizing conditions of fluoride（F）, aluminium（Al）, calcium（Ca）, magnesium（Mg）, phosphorus（P）, copper（Cu）, zinc（Zn）, iron（Fe） and manganese（Mn） in brick tea type skeletal fluorosis patients. Methods＂ In brick-tea fluorosis areas Chenbaerhu＇Qi, Ewenke＇Qi in Inner Mongolia, 73 skeletal fluorosis patients and 64 controls rarely drinking brick tea were enrolled, and their hair and urine were sampled. F was determined by ion selective electrode method and the concentrations of A1,Ca,Mg,P,Cu,Zn,Fe,Mn in samples were detected by inductively coupled plasma-atomic emission spectroscopy （ICP-AES）. Probability distributions tests and Kruskal-Wallis ANOVA, Median test of data were analyzed with the help of Stat 6.0. Results Concentrations of A1, Fe and P in hair and urinary Mn in skeletal fluorosis patients were normally distributed, and so were hair A1, hair P, urinary P and urinary A1 in control group. Kruskal-Wallis ANOVA, median test showed that hair A1, hair Mn, urinary AI and Ca concentrations in skeletal fluorosis patients were obviously higher than those in control group （P 〈 0.05）, respectively. However, hair Zn and urinary P in skeletal fluorosis patients were much lower than that in control group （P 〈 0.05）, respectvely. Conclusions Brick-tea skeletal fluorosis patients have metabolizing disorder of A1,Mn,Zn, Ca,P, and the roles of Al, Mn and Zn in the development of brick-tea skeletal fluorosis should be further studied.

关 键 词：茶 氟化物中毒 元素 毛发 尿 

分 类 号：R686[医药卫生—骨科学]