CD_4^+CD_(25)^+调节性T细胞在儿童特发性血小板减少性紫癜患者中的表达及意义  

Expression and significance of CD_4^+CD_(25)^+ regulatory T lymphocytes in child with idiopathic thrombocytopenic purpura

作　　者：涂亚兰 

机构地区：[1]浙江省桐庐县妇幼保健院,浙江桐庐311500

出　　处：《现代中西医结合杂志》2007年第11期1454-1455,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨儿童特发性血小板减少性紫癜(ITP)患者CD4+CD25+调节性T细胞的表达及意义。方法用流式细胞术检测27例ITP患儿和21例健康儿童外周血T淋巴细胞亚群的比例,以及CD4+T淋巴细胞表面CD25、FasL和Fas的表达率。结果ITP患儿CD3、CD4、CD4/CD8比值与对照组比较显著降低,CD4+CD25+调节性T细胞明显减少,CD4+CD25-细胞无明显改变,CD4+FasL+增多,CD4+Fas+减少。结论儿童ITP患者CD4+CD25+调节性T细胞显著减少,破坏自身免疫耐受,在ITP的发病中起重要作用。Objective It is to discuss the expression and significance of CD4^＋ CD25^＋ regulatory T lyrnphocytes in child with idiopathic thrombocytopenic purpura （ITP）. Methods The ratio of the peripheral T lymphocyte subgroup in 27 children with ITP and 21 healthy children and the expression ratio of CD2s, FasL and Fas on CD4^＋ T lymphocytes surface were detected with flow cytometry. Results CD3, CD4 and CD4/CDs ratio in obviously lower than that in control group, CD4^＋ CD25^＋ regulatory T lymphocytes obviously decreased, CD4^＋ CD25^- lymphocytes had no obvious changes, CD4^＋ FasL ^＋ lymphocytes was increased and CD4^＋ Fas^＋ lmyphocytes was decreased. Conclusion CD4^＋ CD25^＋ regulatory T lymphocytes in ITP children were significantly decreased, destroyed autospecific immune tolerance and played an important role in the pathogenesis of ITP.

关 键 词：儿童 特发性血小板减少性紫癜 CD4^+ CD25^+ 调节性T细胞 

分 类 号：R392.11[医药卫生—免疫学]