新西兰兔腹主动脉缩窄术(肾动脉上)后心肌收缩和舒张功能的变化  

Changes of Systolic and Diastolic Function after Constriction of Abdominal Aorta (above Renal Artery) in New-Zealand Rabbit

作　　者：蔡毅[1] 何昆仑[1] 闫丽辉[1] 冷文修[1] 范利[1] 

机构地区：[1]解放军总医院老年心肾科,北京市100853

出　　处：《中国康复理论与实践》2007年第3期245-247,F0003,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京市自然科学基金课题面上项目(7052063);全军"十五"课题资助项目(04T6002)

摘　　要：目的建立高血压病导致的射血分数正常性心力衰竭的动物模型。方法雄性新西兰兔35只随机分为2组:手术组(n=25)在右侧肾动脉上1cm处行腹主动脉缩窄术;假手术组(n=10)作为对照组。术后观察有无心衰的临床表现,手术前后监测血流动力学变化并定期复查超声心动图。结果手术组于术后2周出现心室肥厚,术后4周出现心衰临床表现、等容舒张期时间延长、左室舒张末压升高以及-dp/dtmax降低。组织Doppler超声提示二尖瓣环舒张早期与舒张晚期波峰比值降低(以上均P<0.05),而射血分数和+dp/dtmax无显著性差异。结论手术组动物出现了心衰的临床表现、左室舒张功能受损但射血分数保持正常,符合人类高血压病导致的射血分数正常性心力衰竭的特点。Objective To establish an animal model of heart failure with preserved ejection fraction （EF） resulting from hypertension. Methods 35 male New-Zealand rabbits were randomly assigned to 2 groups： constriction was performed at the abdominal aorta 1 cm just above right renal artery in operated group （n=25）, and the sham-operated animals were taken as control group （n=10）. The clinical manifestations of heart failure were followed up carefully. Systolic and diastolic function, and systemic hemodynamics were investigated with echocardiography and left ventricle catheter. Results In operated group, marked ventricular hypertrophy was observed 2 weeks after operation. 4 weeks after operation, the clinical manifestations of heart failure presented, and IVRT and LVEDP increased, and -dp/dtmax decreased. Tissue doppler image indicated that e/a ratio of annulus of mitral valve decreased （P〈0.05）. However, EF and ＋dp/dtmax were preserved. Conclusion The operated animals presented the clinical manifestation of heart failure, and diastolic function of left ventricle injured, however, ejection fraction was preserved, which corresponded with the character of heart failure with preserved ejection fraction resulting from hypertension.

关 键 词：舒张性心力衰竭 射血分数正常性心力衰竭 模型 兔 腹主动脉缩窄术 

分 类 号：R541.6[医药卫生—心血管疾病]