氯诺昔康复合芬太尼在皮下术后镇痛的应用  

Evaluation of subcutaneous postoperative analgesia with lornoxicam plus fentanyl

作　　者：陈信发[1] 张舟[1] 郑妈迎[1] 吴励文[1] 

机构地区：[1]广东省汕头市中心医院麻醉科,广东汕头515031

出　　处：《海南医学》2007年第4期33-34,共2页Hainan Medical Journal

摘　　要：目的探讨氯诺昔康复合芬太尼在皮下术后镇痛的镇痛效果,安全性及实用性。方法51例ASAⅠ～Ⅱ级的择期手术病人,术毕所有病人静脉注射氯诺昔康8mg,作为镇痛的负荷剂量。随机分成两组:皮下镇痛组,n=26;静脉镇痛组,n=25。以1ml/h恒速进行术后镇痛,药物配制(两组相同):氯诺昔康15μg·kg-1·h-1+芬太尼0.1μg·kg-1·h-1。记录术后4、8、12、24、36、48h视觉模拟评分(VAS)和不良反应。结果镇痛效果VAS评分两组间无统计学意义(P>0.05),两组恶心、呕吐发生率无统计学意义。静脉镇痛组有4例因套管针脱出,需重新静脉穿刺。结论氯诺昔康复合芬太尼用于皮下术后镇痛,能达到良好的镇痛效果。相对于静脉镇痛组,氯诺昔康复合芬太尼用于皮下术后镇痛,操作更加方便、安全。Objective To evaluate the efficacy, safety and availability of lomoxicam plus fentanyl for subcutaneous postoperative analgesia. Methods 51 patients （ASA Ⅰ-Ⅱ ） were randomly divided into 2 groups： Group scPCA （n=26） and Group PICA （n=25）. All patients were infused loading dose of lomoxicara 8mg after the operation. Postoperative analgesia is under the fixed vdocity 1ml/h. The mixture of lomoxicam plus fentanyl： lomoxicam 15μg·kg^-1·h^-1 plus fentanyl 0.1μg·kg^-1·h^-1. The VAS scores at 4, 8, 12,24,36 and 48 hours after surgery were used to evaluate the analgesic response and adverse effects. Results No significant difference between the two analgesic groups in the VAS evaluation （P〉0. 05 ）. No significant difference of nausea and vomit between the two analgesic groups. During the period of postoperative analgesia, 4 cases were found the needle falling off, need to be intravenous injection again in group PICA, Conclusions The significant analgesia was achieved in group SCPCA with lomoxicam plus fentanyl. Comparing the group PICA, group SCPCA with lomoxicam plus fentanyl for postoperative analgesia is a convenient and safe methods.

关 键 词：氯诺昔康 芬太尼 皮下注射 镇痛 术后 

分 类 号：R614[医药卫生—麻醉学]