脉苏散对糖尿病肢体动脉闭塞症血栓素B_2及6-酮-前列腺素F_(1α)的影响  

Effect of Maisu medicinal powder on thromboxane B_2 and 6-keto-prostaglandin F_(1α) in Patients with Diabetic Arterial Obliteration

作　　者：侯玉芬[1] 王雁南[1] 张玥[1] 刘明[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医药大学学报》2007年第2期112-114,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：山东省中医管理局资助课题(编号:200350)

摘　　要：目的:观察脉苏散治疗糖尿病肢体动脉闭塞症(DAO)血管内皮功能失调的疗效及安全性。方法:选取60例DAO患者,随机分为两组,均常规应用降糖药物及丹参注射液治疗,治疗组予脉苏散治疗,对照组予通心络治疗,疗程60 d。观察两组治疗前后症状体征、肝肾功能、血液流变学、血栓素B2和6-酮-前列腺素F1α变化情况,评价其综合疗效。结果:两组患者均未出现严重不良反应。治疗组和对照组愈显率分别为43.3%、76.6%,两组比较有显著性差异(P<0.05)。治疗后两组血栓素B2、血浆黏度、红细胞聚集指数及纤维蛋白原均较治疗前降低,有显著性差异(P<0.05);6-酮-前列腺素F1α较治疗前升高,有显著性差异(P<0.05)。结论:脉苏散组方符合DAO中医辨病辨证规律,可有效改善患者的血液流变性和血管内皮功能,疗效可靠,安全性良好。Objective： To investigate the therapeutic effect and security of Maisu medicinal powder on vascular endothelial dysfunction in the diabetic arterial obliteration （DAO）. Methods： 60 patients with DAO were divided into two groups by random. Maisu medicinal powder and Tongxinluo capsule were applied in the treatment group and control group respectively. All patients were treated by hypoglycemic agents and Danshen injection as conventional treatment. 60 days later, the changes of the symptoms and physical signs, the function liver and kidney, hemorheology, thromboxaneB2 （TXB2） and 6- keto-prostaglandin F1α（6-keto-PGF1α） before and after treatment were compared. Results： The adverse reaction have not happen among all patients. The therapeutic results of the treatment group was better than those of the control group with statistically differences. Conclusion： The makeup of Maisu medicinal powder is accord with the laws of differetial diagnosis in traditional Chinese medicine. It can effectively improved the hemorheology and endothelial function of DAO and have obvious curative effects as well as safety.

关 键 词：脉苏散 糖尿病肢体动脉闭塞症 血栓素B2 6-酮-前列腺素F1Α 临床研究 

分 类 号：R259.872[医药卫生—中西医结合]