食物过敏原试验对过敏性紫癜病因分析和治疗意义  

EVALUATION OF THE FOOD ALLERGEN TEST IN ETIOLOGICAL ANALYSIS AND TREATMENT GUIDANCE OF HENOCH-SCHONLEIN PURPURA IN CHILDREN

作　　者：王业军[1] 张秋业[2] 徐静[3] 

机构地区：[1]青岛市妇女儿童医疗保健中心内一科,山东青岛266011 [2]青岛大学医学院附属医院儿内科 [3]青岛市妇女儿童医疗保健中心急诊科

出　　处：《齐鲁医学杂志》2007年第2期95-97,共3页Medical Journal of Qilu

摘　　要：目的探讨体外食物过敏原试验对确定儿童过敏性紫癜(HSP)病因和指导饮食控制辅佐治疗HSP的价值。方法选择60例HSP病儿(HSPⅠ组)为研究对象,以30例正常儿童为对照组,采用酶免疫分析法进行体外食物过敏原检测;以45例未行食物过敏原试验的HSP病儿(HSPⅡ组)为对照组,比较不同饮食控制疗法的近期疗效。结果HSPⅠ组血清总IgE阳性率、过敏原检测阳性率与正常对照组比较差异有极显著意义(2χ=8.038、7.500,P<0.01);HSPⅠ组中同时对两类或两类以上食物过敏原检测阳性率高于正常对照组(2χ=4.821,P<0.05);HSPⅠ组海产品类和蔬菜类检测阳性率明显高于对照组(χ2=4.821、4.226,P<0.05)。HSPⅠ组病儿根据体外食物过敏原试验结果进行饮食控制,与常规行忌食动物蛋白和海产品类饮食的HSPⅡ组比较,随访3个月期间紫癜反复或复发率差异显著(χ2=4.507,P<0.05)。结论过敏原检测有助于确定HSP的病因;海产品和蔬菜类食物过敏为本地区儿童HSP的重要诱发因素;通过针对性饮食控制可有效控制或减少HSP的反复或复发,对HSP的防治有重要临床意义。Objective To evaluate the food allergen test in the etiology analysis of Henoch-Schonlein purpura （HSP） and alimentary control in the treatment of HSP in children. Methods Sixty children with HSP （HSP Ⅰ group） and 30 healthy children as normal control were studied via enzyme immunoassay to test food allergen. Another 45 children with HSP not undergoing the test were included as experimental control （HSP Ⅱ group）. Results The positive rate of the total serum IgE and allergen in the HSP Ⅰ group was significantly higher than that of the normal control group （X^28= 038,7. 500;P〈0.01）. The percentage of children in the HSP Ⅰ group, who were positive to two, or more than two food allergens, were higher than that of the normal control group （X^2 =4. 821 ,P〈0.05）. The positive rates of sea food and vegetables in the HSP I group were significantly higher than those in the control group （X^2=4. 821,4. 226;P〈0. 05）. Alimentary control was carried out in children of HSP Ⅰgroup on the basis of the test results. The followed up lasted for three months. The recurrence in group I was significantly lower than that in HSP Ⅱ group （X^2=4. 507,P〈0.05）. Conclusion Allergen test is helpful to determine the causes of HSP. Sea food and vege tables are the main inducers of allergy in children of this area. The directed alimentary control can effectively handle or reduce the recurrence of HSP, which is of great importance in the prevention and treatment of HSP.

关 键 词：紫癜 过敏性 过敏原 诊断 治疗 儿童 

分 类 号：R725.93[医药卫生—儿科]