浆细胞样树突状细胞在感染性、免疫性疾病中的研究进展  

Research progress on plasmacytoid dendritic cells in infective and immune diseases

作　　者：余艳[1] 谢幸[1] 吕卫国（审校者）[2] 

机构地区：[1]浙江大学医学院附属妇产科医院中心实验室,杭州310031 [2]浙江大学医学院附属妇产科医院

出　　处：《国际免疫学杂志》2007年第2期88-91,共4页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30471811）

摘　　要：浆细胞样树突状细胞（PDC）来源于淋巴系造血干／祖细胞，能选择性的诱导免疫应答，并在一定条件下诱导免疫耐受，在抗病毒感染中起重要作用，并可能参与了某些自身免疫性疾病的发生。PDC产生的Ⅰ型IFN（IFN-α／β）在抗病毒过程中很关键，而一定条件下PDC诱导的免疫耐受与调节性T细胞的产生相关。自身免疫性疾病中持续高水平的Ⅰ型IFN提示PDC可能参与此类疾病的发病机制。Plasmacytoid dendritic cells （PDC） derive from a common lymphoid progenitor, they can induce either innate and adaptive immune responses or antigen-specific suppressions of immune responses in special conditions. So PDCs appear not only to be beneficial to the host＇ s immune responses against viralinfections, but also to contribute to allergic reactions, such as autoimmune diseases. Type I interferon （IFN-α/β） produced by PDCs ,plays an important role in antiviral immune responses. Anergic state induced by PDCs is correlated with the generation of regulatory T cells. High levels of type I IFN in autoimmune diseases indicate the possibility of PDC＇ s involving in the pathogenesis of these diseases.

关 键 词：浆细胞样树突状细胞 感染 免疫 

分 类 号：R59[医药卫生—内科学]