树突状细胞特异表面分子DC-SIGN的研究进展  

Advance in the research of DC-SIGN, a DC-specific surface molecule

作　　者：孔鹏洲[1] 汤华[1] 

机构地区：[1]天津医科大学生命科学中心实验室,300070

出　　处：《国际免疫学杂志》2007年第2期113-117,共5页International Journal of Immunology

摘　　要：DC-SIGN是一种特异表达于树突状细胞（DC）表面的Ⅱ型跨膜蛋白，在机体生理和病理免疫调节中发挥着重要作用，可以与ICAM-3结合，从而介导DC与T细胞的相互作用，其CRD区可以与HIV-1、HCV、结核杆菌等多种病原体表面糖蛋白结合，从而促进病原体感染。最近的研究表明DCSIGN与肿瘤免疫、免疫逃避也密切相关。DC-specific ICAM-3-grabbing nonintegrin （DC-SIGN）, a C-type lectin expressed in DCs, plays an important role in immune regulation in physiological and pathological conditions, such as inflammation,autoimmune disease, and cancer. DC-SIGN mediates the interaction of DC and T lymphocytes by binding to ICAM-3. And DC-SIGN is known to bind with high affinity to envelope glycoproteins of various pathogens, including human immunodeficiency virus （HIV） and hepatitis C virus, as well as to Mycobacterium tuberculosis. The new research showed DC-SIGN is related to tumor immunity also.

关 键 词：DC-SIGN HIV-1 分子机制 肿瘤 

分 类 号：R3[医药卫生—基础医学]