真菌血症31例临床分析  

Clinical analysis of 31 patients with fungemia

作　　者：马晓波[1] 吕晓菊[1] 牛菲菲[1] 过孝静[1] 潘晓夫[1] 高燕渝[1] 

机构地区：[1]四川大学华西医院感染性疾病中心,成都610041

出　　处：《中国感染与化疗杂志》2007年第1期19-21,共3页Chinese Journal of Infection and Chemotherapy

摘　　要：目的对真菌血症的临床及微生物学特征进行分析,为临床诊治提供参考。方法收集2004年8月—2005年12月期间我院31例真菌血症患者的临床资料进行回顾分析。结果超过80%的真菌血症患者患有2种或以上的基础疾病。半数以上患者均有导管留置,而且83．9%患者在血培养采样前1周内均不同程度使用抗菌药物。31例真菌血症中,24例(77．4%)与念珠菌有关,但仅3例由白念珠菌引起,念珠菌血症患者的病死率为45．8%。不同念珠菌对抗真菌药物存在不同程度的耐药率。结论真菌血症多发生于基础疾病严重者,由非白念珠菌导致的败血症在真菌血症中占很大比例;部分真菌对氟康唑、伊曲康唑耐药。Objective To investigate the epidemiology of fungemia and provide evidence for clinical therapy. Methods A retrospective survey was done with the 31 cases of fungemia in our hospital from August 2004 to November 2005. Results More than 80 % of the patients suffered from two and more underlying diseases. Over a half of infections developed following placement of catheters. And 83.9%0 of the patients had a history of antimicrobial agents use before blood culture. The pathogens of 24 （77. 4%） cases were associated with Candida spp. Only 3 strains were C. albicans. The mortality rate of candidemia was 45.8 %. Different Candida species had different resistance rates to antifungal agents. Conclusions Fungemia patients often have serious underlying diseases. Most fungemia cases were candidemia caused by non-C, albicans. Some fungal pathogens are resistant to fluconazole and itraconazole.

关 键 词：真菌血症 病原菌 念珠菌属 

分 类 号：R519[医药卫生—内科学]