针刺对早期佐剂性关节炎模型大鼠血浆、下丘脑、垂体及淋巴结β-EP水平的影响  

Effect of acupuncture on β-EP levels of plasma,hypothalamus, pituitary and lymph node in rats with adjuvant-induced arthritis

作　　者：张露芬[1] 闫明茹[1] 程金莲 郑宇[1] 朱文莲[1] 严洁[1] 刘建桥[3] 

机构地区：[1]北京中医药大学针灸学院,北京100029 [2]北京市中医院 [3]北京市海淀医院

出　　处：《北京中医药大学学报》2007年第1期70-72,F0003,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：北京市自然科学基金资助项目(No.7052037)

摘　　要：目的观察针刺对佐剂型关节炎大鼠模型血浆、下丘脑、垂体、淋巴结β-内啡肽(β-EP)水平变化的影响。方法以佐剂性关节炎模型大鼠作为研究对象,选取“任脉六穴”(膻中、玉堂、紫宫、华盖、璇玑、天突)和“关元穴”进行电针刺激,采用放射免疫法测定血浆、下丘脑、垂体、淋巴结β-EP水平。结果针刺可以调节不同组织的β-EP水平,针刺后,下丘脑β-EP水平呈降低趋势,血浆、垂体、淋巴结β-EP水平呈升高趋势。结论针刺可抑制早期佐剂性关节炎模型的炎症反应,调节机体各组织器官的β-EP水平从而抑制或减轻伤害性刺激对机体的损伤。Objective To observe the influence of acupuncture onβ-EP levels of plasma, hypothalamus, pituitary and lymph node in rats with adjuvant - induced arthritis. Methods The adjuvant arthritis model rats were given electro-acupuncture on the ＂six points of conception vessel （CV）＂, tanzhong （ CV17 ）, yutang （ CV18 ）, （ CV21 ）, and on the acupoint of guanyuan （ CV4 ）. zigong （ CV19 ）, huagai （ CV20 ） and xuanji Radio-immunity was used to determine the β-EP levels in serum, hypothalamus, pituitary and lymph node. Results The acupuncture could regulate theβ-EP levels in different tissues. After the acupuncture the β-EP level in hypothalamus showed depressed tendency, while in plasma, pituitary and lymph node, presented elevated tendency. Conclusion The acupuncture can inhibit the inflammatory reaction and regulate the β-EP levels of different tissues and organs to lighten the damage caused by harmful stimulation.

关 键 词：针刺 佐剂性关节炎 Β-内啡肽 

分 类 号：R246.1[医药卫生—针灸推拿学]