纳米铁核素靶向治疗肿瘤的辐射效应研究  

Study of Radiation Effects on Targeting Therapy in Nanometer-iron Nuclide

作　　者：刘建庭[1] 熊平[1] 景娜[2] 王玉[2] 

机构地区：[1]中南大学信息物理工程学院生物医学工程研究所,湖南长沙410083 [2]山西省肿瘤医院乳腺放疗科,山西太原030013

出　　处：《中国医学物理学杂志》2007年第2期79-82,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金资助项目(No.30371626)

摘　　要：目的:综合考察纳米铁核素(59Fe)的照射剂量率和照射时间对杀死肿瘤细胞的影响,为低剂量率的β粒子放射性核素靶向疗法提供指导。方法:采用的三个肿瘤细胞系为:SKBR-3乳腺癌、U-118MG神经胶质瘤和A-431宫颈癌;实验模型为:在每一个样品中取103个肿瘤细胞,用低剂量率的β粒子照射;初始剂量率为:0.1 Gy/h～0.8 Gy/h;持续照射时间为:1天、3天或者7天。结果:分别用0.2 Gy/h～0.3 Gy/h和0.4 Gy/h～0.6 Gy/h的剂量率连续照射肿瘤细胞7天和3天,能够将所有肿瘤细胞样品中的细胞杀死。细胞的总辐射剂量为30 Gy～40 Gy。而用0.8 Gy/h的剂量率照射24小时后,仅SKBR-3细胞被杀死,其它肿瘤细胞系的所有细胞都能自动修复。结论:在低剂量率的β粒子放射性核素靶向疗法中,该实验结果为照射剂量率和照射时间的确定提供了指导。Objective： The purpose of this study was to identify the effect of different dose rate and expasure time on the tumor cells, which can provide a series of direction for the targeted radionuclide therapy applying low dose rate beta irradiation. Methods： Three tumor cell lines, U- 118MG gliomas, A-431 cervical squamous carcinoma and SKBR-3 breast cancer,were used. An experimental model with 10^3 tumor cells in each sample was irradiated with low dose rate beta particles. The initial dose rates were in the range of 0.1 Gy/h-0.8 Gy/h, and the cells were continuously exposed for l day, 3days or 7days. Results： Continuous irradiation with dose rates of 0,2 Gy/h-0.3 Gy/h and 0,4 Gy/h-0.6 Gy/h for 7days and 3 days, respectively, could kill all cells in all tumor cell samples, The given total radiation doses was 30 Gy-40 Gy, However, when exposed for 24 h with about 0.8 Gy/h, only the SKBR-3 cells were successfully treated and all the other cell types recovered. Conclusions： The results served as a guideline for the combinations of dose rate and exposure time. It is necessary to kill tumor cells that low dose rate beta irradiation should be applied.

关 键 词：剂量率 纳米铁核素 Β粒子 靶向治疗 

分 类 号：R817.1[医药卫生—影像医学与核医学] R730.55[医药卫生—放射医学]