有氧运动对老年原发性高血压患者血小板表面糖蛋白受体的影响  

Influences of aerobic exercises on platelet membrane glycoproteins in elderly hypertensives

作　　者：李玉峰[1] 王士雯[1] 赵玉生[1] 

机构地区：[1]解放军总医院老年心血管病研究所,老年心血管病救治中心,北京100853

出　　处：《中国康复医学杂志》2007年第3期206-208,共3页Chinese Journal of Rehabilitation Medicine

基　　金：老年高血压康复基础及临床研究;中央保健委员会专项基金重点资助课题资助(B020)

摘　　要：目的:探讨规律运动对老年原发性高血压患者血小板表面活化分子标志蛋白及血小板聚集的影响。方法:将我院门诊就诊的老年原发性高血压患者212例随机分为两组,对照组103例,实验组109例,后者在常规治疗的基础上采取中等量的运动疗法3个月。采用流式细胞术(FCM)以单克隆抗体分子作为探针,分别测定两组患者运动前后血小板膜上CD62P、CD61的阳性百分率(CD62P%、CD61%)及血小板聚集率。结果:进行运动疗法3个月后,对照组与实验组两组患者,收缩压分别为160±4.6mmHg及156±4.5mmHg(P<0.05);舒张压分别为92±4.2mmHg及88±2.9mmHg(P<0.01);血小板膜上CD62P阳性百分率分别为17.3%±2.2%及12.5%±3.1%(P<0.01)、CD61阳性百分率分别为20.3%±2.4%及16.2%±2.3%(P<0.01);血小板聚集率分别为:71.4%±4.6%及62.3%±3.4%(P<0.01)。结论:规律运动不仅可以降低老年高血压患者的血压,而且能够降低血小板表面活化受体分子的密度,降低血小板聚集,有利于防止高血压患者的血栓前状态的形成。Objective： To explore influences of aerobic exercise on platelet membrane glycoproteins in elderly hypertensives. Method： Two hundred and twelve elderly patients with primary hypertension were divided into exercises group （n=109） and control group （n=103） . The exercises with moderate intensity was 30min persession, 5 sessions perweek for 3 months.The platelet membrane glycoprotein CD62P, CD61 （Ⅲa） were determined by flow cytometric analysis and platelet aggregation rate was measured before and after regular aerobic exercises. Result： After three months of aerobic exercises, the blood pressure （mmHg）（SBP：160±4.6 vs 156±4.5,P〈0.05; DBP-92±4.2 vs 88±2.9,P〈0.01）and the positive percent of platelet membrane glycoprotein CD62P （%）（17.3±2.2 vs 12.5±3.1,P〈0.01）, CD61（ma）（%）（20.3±2.4 vs 16.2±2.3,P〈0.01） and platelet aggregating ratio（%）（71.4±4.6 vs 62.3±3.4,P〈0.01） in aerobic exercises group decreased significantly than with those in control group. Conclusion： Regular aerobic exercises can decrease not only the blood pressure, but also the positive percent of platelet membrane glyeoprotein and platelet aggregation rate in elderly patients with primary hypertension.

关 键 词：原发性高血压病 有氧运动 血小板膜糖蛋白受体 血小板聚集率 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]