Selective Synthesis of [2＋2] Macrocyclic Schiff Bases from Chiral 1,4-Diamines  

作　　者：诸海滨 胡大华 董华泽 李根喜 苟少华 

机构地区：[1]Department of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, Jiangsu 210093, China [2]Department of Biochemistry, Nanjing University, Nanjing, Jiangsu 210093, China

出　　处：《Chinese Journal of Chemistry》2007年第3期343-345,共3页中国化学（英文版）

基　　金：Project supported by National Natural Science Foundation of China （Nos. 20271026 and 20391001） and Postdoctoral Research Support Fund of Jiangsu Province （No. 0502005B）.

摘　　要：[2＋2] macrocyclic Schiff bases of three kinds have been synthesized from chiral 1,4-diamines by use of different methods. Macrocyclic Schiff bases 1a-1c have been selectively obtained based on a non-templated dilution method from chiral 1,4-diamines a-c and dialdehyde DA1, whereas macrocycles 2a-2c have been selectively produced from reaction of diamines a-c and dialdehyde DA2 in the presence of boric acid as templates. Macrocyclic Schiff bases 3a-3c have been afforded in high selectivity from diamines a-c and dialdehyde DA3 by means of sodium-template. All the titled compounds have been confirmed by ^1H NMR and ESI-MS analyses.[2＋2] macrocyclic Schiff bases of three kinds have been synthesized from chiral 1,4-diamines by use of different methods. Macrocyclic Schiff bases 1a-1c have been selectively obtained based on a non-templated dilution method from chiral 1,4-diamines a-c and dialdehyde DA1, whereas macrocycles 2a-2c have been selectively produced from reaction of diamines a-c and dialdehyde DA2 in the presence of boric acid as templates. Macrocyclic Schiff bases 3a-3c have been afforded in high selectivity from diamines a-c and dialdehyde DA3 by means of sodium-template. All the titled compounds have been confirmed by ^1H NMR and ESI-MS analyses.

关 键 词：1 4-diamine MACROCYCLE Schiff base TEMPLATE 

分 类 号：O625.637[理学—有机化学]